Personalized treatment of patients with very early hepatocellular carcinoma

Alessandro Vitale, Markus Peck-Radosavljevic, Edoardo G. Giannini, Eric Vibert, Wolfgang Sieghart, Sven Van Poucke, Timothy M. Pawlik

Research output: Contribution to journalReview articlepeer-review

59 Scopus citations


Hepatocellular carcinoma (HCC), in its very early stage, is heterogeneous both in terms of liver function (i.e., presence or absence of portal hypertension, model for end-stage liver disease score, Child-Pugh score 5 or 6, bilirubin level) and tumor characteristics (i.e., location, alpha-fetoprotein values, pathological features such as microvascular invasion, tumor grade and satellitosis). Existing evidence in comparing different curative options for patients with very early HCC is poor due to small sample sizes and lack of solid subgroup analyses. Large observational studies are available, with the potential to identify effective interventions in different subgroup of patients and to discover which treatments work “in a real world setting”. These studies suggest some important treatment selection strategies in very early HCC patients. According to extent of liver resection, and liver function, percutaneous ablation or liver resection are the recommended first line therapies in these patients. Laparoscopic surgery (resection or ablation) is the preferable strategy when the tumor is in the surface of the liver or close to extra-hepatic organs. Due to scarce donor resources and competition with patients at high transplant benefit (HCC patients unsuitable for non-transplant radical therapies and non-HCC patients with decompensated cirrhosis), transplantation is recommended only as second line therapy in patients with very early stage HCC in case of tumor recurrence or liver failure after ablation or liver resection.

Original languageEnglish (US)
Pages (from-to)412-423
Number of pages12
JournalJournal of Hepatology
Issue number2
StatePublished - Feb 1 2017
Externally publishedYes


  • Ablation
  • Evidence based treatment
  • Liver resection
  • Liver transplantation
  • Personalized approach
  • Very early hepatocellular carcinoma

ASJC Scopus subject areas

  • Hepatology


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