Personalized Preventive Medicine: Genetics and the Response to Regular Exercise in Preventive Interventions

Claude Bouchard; Ligia M. Antunes-Correa; Euan A. Ashley; Nina Franklin; Paul M. Hwang; C. Mikael Mattsson; Carlos E. Negrao; Shane A. Phillips; Mark A. Sarzynski; Ping yuan Wang; Matthew T. Wheeler

doi:10.1016/j.pcad.2014.08.005

Personalized Preventive Medicine: Genetics and the Response to Regular Exercise in Preventive Interventions

Claude Bouchard, Ligia M. Antunes-Correa, Euan A. Ashley, Nina Franklin, Paul M. Hwang, C. Mikael Mattsson, Carlos E. Negrao, Shane A. Phillips, Mark A. Sarzynski, Ping yuan Wang, Matthew T. Wheeler

School of Medicine

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

Regular exercise and a physically active lifestyle have favorable effects on health. Several issues related to this theme are addressed in this report. A comment on the requirements of personalized exercise medicine and in-depth biological profiling along with the opportunities that they offer is presented. This is followed by a brief overview of the evidence for the contributions of genetic differences to the ability to benefit from regular exercise. Subsequently, studies showing that mutations in TP53 influence exercise capacity in mice and humans are succinctly described. The evidence for effects of exercise on endothelial function in health and disease also is covered. Finally, changes in cardiac and skeletal muscle in response to exercise and their implications for patients with cardiac disease are summarized. Innovative research strategies are needed to define the molecular mechanisms involved in adaptation to exercise and to translate them into useful clinical and public health applications.

Original language	English (US)
Pages (from-to)	337-346
Number of pages	10
Journal	Progress in Cardiovascular Diseases
Volume	57
Issue number	4
DOIs	https://doi.org/10.1016/j.pcad.2014.08.005
State	Published - Jan 1 2015

Keywords

Endothelium
Genetics
Individual differences
Mitochondria
Personalized medicine

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.pcad.2014.08.005

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Bouchard, C., Antunes-Correa, L. M., Ashley, E. A., Franklin, N., Hwang, P. M., Mattsson, C. M., Negrao, C. E., Phillips, S. A., Sarzynski, M. A., Wang, P. Y., & Wheeler, M. T. (2015). Personalized Preventive Medicine: Genetics and the Response to Regular Exercise in Preventive Interventions. Progress in Cardiovascular Diseases, 57(4), 337-346. https://doi.org/10.1016/j.pcad.2014.08.005

Bouchard, C, Antunes-Correa, LM, Ashley, EA, Franklin, N, Hwang, PM, Mattsson, CM, Negrao, CE, Phillips, SA, Sarzynski, MA, Wang, PY & Wheeler, MT 2015, 'Personalized Preventive Medicine: Genetics and the Response to Regular Exercise in Preventive Interventions', Progress in Cardiovascular Diseases, vol. 57, no. 4, pp. 337-346. https://doi.org/10.1016/j.pcad.2014.08.005

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abstract = "Regular exercise and a physically active lifestyle have favorable effects on health. Several issues related to this theme are addressed in this report. A comment on the requirements of personalized exercise medicine and in-depth biological profiling along with the opportunities that they offer is presented. This is followed by a brief overview of the evidence for the contributions of genetic differences to the ability to benefit from regular exercise. Subsequently, studies showing that mutations in TP53 influence exercise capacity in mice and humans are succinctly described. The evidence for effects of exercise on endothelial function in health and disease also is covered. Finally, changes in cardiac and skeletal muscle in response to exercise and their implications for patients with cardiac disease are summarized. Innovative research strategies are needed to define the molecular mechanisms involved in adaptation to exercise and to translate them into useful clinical and public health applications.",

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note = "Funding Information: C Bouchard is partially supported by the John W. Barton, Sr. Chair in Genetics and Nutrition. Research on the HERITAGE Family Study was supported for over 20 years by the National Institutes of Health (HL-45670). PY Wang and PM Hwang are supported by the Division of Intramural Research, National Heart, Lung, and Blood Institutes (NHLBI) and by a Bench-to-Bedside of the National Institutes of Health. LM Antunes-Correa was supported by Funda{\c c}{\~a}o de Amparo {\`a} Pesquisa do Estado de S{\~a}o Paulo FAPESP (2013/15651-7 and 2013/07607-8). CE Negrao was supported by CNPq (301867/2010-0), FAPESP (2010/50048-1 and 2013/07607-8), and, in part, by Funda{\c c}{\~a}o Zerbini. Publisher Copyright: {\textcopyright} 2014 Elsevier Inc.",

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Personalized Preventive Medicine: Genetics and the Response to Regular Exercise in Preventive Interventions

Abstract

Keywords

ASJC Scopus subject areas

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