Persistent spiking activity underlies working memory

Christos Constantinidis; Shintaro Funahashi; Daeyeol Lee; John D. Murray; Xue Lian Qi; Min Wang; Amy F.T. Arnsten

doi:10.1523/JNEUROSCI.2486-17.2018

Persistent spiking activity underlies working memory

Christos Constantinidis
, Shintaro Funahashi
, Daeyeol Lee
, John D. Murray
, Xue Lian Qi
, Min Wang
, Amy F.T. Arnsten

Research output: Contribution to journal › Article › peer-review

Abstract

Persistent activity generated in the PFC during the delay period of working memory tasks represents information about stimuli held in memory and determines working memory performance. Alternative models of working memory, depending on the rhythmicity of discharges or exclusively on short-term synaptic plasticity, are inconsistent with the neurophysiological data.

Original language	English (US)
Pages (from-to)	7020-7028
Number of pages	9
Journal	Journal of Neuroscience
Volume	38
Issue number	32
DOIs	https://doi.org/10.1523/JNEUROSCI.2486-17.2018
State	Published - Aug 8 2018
Externally published	Yes

Keywords

Delay period
Monkey
Neurophysiology
Prefrontal cortex
Working memory

ASJC Scopus subject areas

General Neuroscience

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10.1523/JNEUROSCI.2486-17.2018

Cite this

@article{78f23059c5cc46f0891665827417911f,

title = "Persistent spiking activity underlies working memory",

abstract = "Persistent activity generated in the PFC during the delay period of working memory tasks represents information about stimuli held in memory and determines working memory performance. Alternative models of working memory, depending on the rhythmicity of discharges or exclusively on short-term synaptic plasticity, are inconsistent with the neurophysiological data.",

keywords = "Delay period, Monkey, Neurophysiology, Prefrontal cortex, Working memory",

author = "Christos Constantinidis and Shintaro Funahashi and Daeyeol Lee and Murray, \{John D.\} and Qi, \{Xue Lian\} and Min Wang and Arnsten, \{Amy F.T.\}",

note = "Funding Information: Received Jan. 8, 2018; revised May 16, 2018; accepted May 25, 2018. This work was supported by National Institutes of Health, National Eye Institute Awards R01 EY017077 and R01 EY016773toC.C.,R01MH112746toJ.D.M.,R01MH108643andR01MH108629toD.L.,andDP1AG047744toA.F.T.A. The authors declare no competing financial interests. Correspondence should be addressed to Dr. Christos Constantinidis, Department of Neurobiology and Anatomy, Wake Forest School of Medicine, Medical Center Blvd, Winston-Salem, NC 27157. E-mail: [email protected]. DOI:10.1523/JNEUROSCI.2486-17.2018 Copyright {\textcopyright} 2018 the authors 0270-6474/18/387020-09\$15.00/0 Publisher Copyright: {\textcopyright} 2018 the authors.",

year = "2018",

month = aug,

day = "8",

doi = "10.1523/JNEUROSCI.2486-17.2018",

language = "English (US)",

volume = "38",

pages = "7020--7028",

journal = "Journal of Neuroscience",

issn = "0270-6474",

publisher = "Society for Neuroscience",

number = "32",

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TY - JOUR

T1 - Persistent spiking activity underlies working memory

AU - Constantinidis, Christos

AU - Funahashi, Shintaro

AU - Lee, Daeyeol

AU - Murray, John D.

AU - Qi, Xue Lian

AU - Wang, Min

AU - Arnsten, Amy F.T.

N1 - Funding Information: Received Jan. 8, 2018; revised May 16, 2018; accepted May 25, 2018. This work was supported by National Institutes of Health, National Eye Institute Awards R01 EY017077 and R01 EY016773toC.C.,R01MH112746toJ.D.M.,R01MH108643andR01MH108629toD.L.,andDP1AG047744toA.F.T.A. The authors declare no competing financial interests. Correspondence should be addressed to Dr. Christos Constantinidis, Department of Neurobiology and Anatomy, Wake Forest School of Medicine, Medical Center Blvd, Winston-Salem, NC 27157. E-mail: [email protected]. DOI:10.1523/JNEUROSCI.2486-17.2018 Copyright © 2018 the authors 0270-6474/18/387020-09$15.00/0 Publisher Copyright: © 2018 the authors.

PY - 2018/8/8

Y1 - 2018/8/8

N2 - Persistent activity generated in the PFC during the delay period of working memory tasks represents information about stimuli held in memory and determines working memory performance. Alternative models of working memory, depending on the rhythmicity of discharges or exclusively on short-term synaptic plasticity, are inconsistent with the neurophysiological data.

AB - Persistent activity generated in the PFC during the delay period of working memory tasks represents information about stimuli held in memory and determines working memory performance. Alternative models of working memory, depending on the rhythmicity of discharges or exclusively on short-term synaptic plasticity, are inconsistent with the neurophysiological data.

KW - Delay period

KW - Monkey

KW - Neurophysiology

KW - Prefrontal cortex

KW - Working memory

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DO - 10.1523/JNEUROSCI.2486-17.2018

M3 - Article

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AN - SCOPUS:85051595942

SN - 0270-6474

VL - 38

SP - 7020

EP - 7028

JO - Journal of Neuroscience

JF - Journal of Neuroscience

IS - 32

ER -

Persistent spiking activity underlies working memory

Abstract

Keywords

ASJC Scopus subject areas

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