Persistent airways disease caused by toluene diisocyanate

D. R. Moller, R. T. McKay, I. L. Bernstein, S. M. Brooks

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


The natural history of isocyanate-induced asthma is not well documented. We evaluated a patient who developed persistent shortness of breath, wheezing, and cough after a massive exposure to toluene diisocyanate (TDI). Despite no further occupational exposures to isocyanates, he continued to have symptoms of asthma and variable airway obstruction 12 yr later. A methacholine inhalation challenge test was markedly positive, and a bronchial challenge test to TDI produced a dual asthmatic response. This report demonstrates that sensitivity to TDI can persist for many years in the absence of further occupational exposure and suggests that some patients with TDI-induced asthma do not recover from their disease after being removed from isocyanate exposure.

Original languageEnglish (US)
Pages (from-to)175-176
Number of pages2
JournalAmerican Review of Respiratory Disease
Issue number1
StatePublished - 1986
Externally publishedYes

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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