Persistence of the effect of the Lung Health Study (LHS) smoking intervention over eleven years

Robert P. Murray, John E. Connett, Cynthia S. Rand, Wei Pan, Nicholas R. Anthonisen

Research output: Contribution to journalArticlepeer-review

50 Scopus citations


Background. Research on the long-term persistence of effects of interventions aimed at smoking cessation is limited. This paper examined the quitting behavior of individuals who were randomized to a smoking cessation intervention (SI) or to usual care (UC), at a point approximately 11 years later. Methods. The initial sample consisted of 5,887 adult smokers in 10 clinics who had evidence of airways obstruction. Two-thirds of the original participants were offered an intensive 12-week smoking cessation intervention. Of these, 4,517 were enrolled in the long-term follow-up study. Results. Randomized group assignment was a strong predictor of smoking behavior after 11 years, in that 21.9% of SI participants and only 6.0% of UC participants maintained abstinence throughout the interval. Logistic regressions identified covariates associated with abstinence. A higher proportion of abstinence was observed in participants that had been assigned to SI (OR = 4.45), were older (OR = 1.11, increment 5 years), had more years of education (OR = 1.05), and fewer cigarettes/day at baseline (OR = 0.90, increment 10 cigarettes). Conclusions. Smokers exposed to an aggressive smoking intervention program and who sustain abstinence for a five-year period are very likely to still be abstinent after 11 years.

Original languageEnglish (US)
Pages (from-to)314-319
Number of pages6
JournalPreventive Medicine
Issue number4
StatePublished - 2002


  • Abstinence
  • Clinical trial
  • Smoking cessation
  • Smoking intervention

ASJC Scopus subject areas

  • Epidemiology
  • Public Health, Environmental and Occupational Health


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