TY - JOUR
T1 - Persistence of HPV infection and risk of high-grade cervical intraepithelial neoplasia in a cohort of Colombian women
AU - Mũoz, N.
AU - Hernandez-Suarez, G.
AU - Méndez, F.
AU - Molano, M.
AU - Posso, H.
AU - Moreno, V.
AU - Murillo, R.
AU - Ronderos, M.
AU - Meijer, C.
AU - Mũoz, Á
N1 - Funding Information:
We thank Andrea Mann at LSHTM, UK for her comments and English proofreading before submitting this paper for publication. Grant support was received from the Colombian Science Council (Colciencias); the Department of Pathology, Vrije Universiteit Medical Center, the Netherlands and from contract (no. V501) between Merck Research Laboratories and the Instituto Nacional de Cancerología, Colombia.
PY - 2009/4/7
Y1 - 2009/4/7
N2 - Little is known about the dynamics of human papillomavirus (HPV) infection and subsequent development of high-grade cervical intraepithelial neoplasia (CIN2/3), particularly in women 30 years of age. This information is needed to assess the impact of HPV vaccines and consider new screening strategies. A cohort of 1728 women 15-85 years old with normal cytology at baseline was followed every 6 months for an average of 9 years. Women with squamous intraepithelial lesions were referred for biopsy and treatment. The Kaplan-Meier method was used to estimate the median duration of infection and Cox regression analysis was undertaken to assess determinants of clearance and risk of CIN2/3 associated with HPV persistence. No difference in the likelihood of clearance was observed by HPV type or woman's age, with the exception of lower clearance for HPV16 infection in women under 30 years of age. Viral load was inversely associated with clearance. In conclusion, viral load is the main determinant of persistence, and persistence of HPV16 infections carry a higher risk of CIN2/3.
AB - Little is known about the dynamics of human papillomavirus (HPV) infection and subsequent development of high-grade cervical intraepithelial neoplasia (CIN2/3), particularly in women 30 years of age. This information is needed to assess the impact of HPV vaccines and consider new screening strategies. A cohort of 1728 women 15-85 years old with normal cytology at baseline was followed every 6 months for an average of 9 years. Women with squamous intraepithelial lesions were referred for biopsy and treatment. The Kaplan-Meier method was used to estimate the median duration of infection and Cox regression analysis was undertaken to assess determinants of clearance and risk of CIN2/3 associated with HPV persistence. No difference in the likelihood of clearance was observed by HPV type or woman's age, with the exception of lower clearance for HPV16 infection in women under 30 years of age. Viral load was inversely associated with clearance. In conclusion, viral load is the main determinant of persistence, and persistence of HPV16 infections carry a higher risk of CIN2/3.
KW - Cervical intraepithelial neoplasia
KW - Human papillomavirus
KW - Persistence
KW - Risk
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U2 - 10.1038/sj.bjc.6604972
DO - 10.1038/sj.bjc.6604972
M3 - Article
C2 - 19293802
AN - SCOPUS:63949083435
SN - 0007-0920
VL - 100
SP - 1184
EP - 1190
JO - British journal of cancer
JF - British journal of cancer
IS - 7
ER -