Peroxisomal-protein import: Is it really that complex?

Stephen J. Gould; Cynthia S. Collins

doi:10.1038/nrm807

Peroxisomal-protein import: Is it really that complex?

Stephen J. Gould, Cynthia S. Collins

School of Medicine

Research output: Contribution to journal › Review article › peer-review

88 Scopus citations

Abstract

Peroxisomal enzymes are synthesized in the cytoplasm and imported post-translationally across the peroxisome membrane. Unlike other organelles with a sealed membrane, peroxisomes can import folded enzymes, and they seem to lack intraperoxisomal chaperones. Here, we propose a mechanistic model for the early steps in peroxisomal-matrix-enzyme import, which might help to explain the unusual features of this process.

Original language	English (US)
Pages (from-to)	382-389
Number of pages	8
Journal	Nature Reviews Molecular Cell Biology
Volume	3
Issue number	5
DOIs	https://doi.org/10.1038/nrm807
State	Published - 2002

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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title = "Peroxisomal-protein import: Is it really that complex?",

abstract = "Peroxisomal enzymes are synthesized in the cytoplasm and imported post-translationally across the peroxisome membrane. Unlike other organelles with a sealed membrane, peroxisomes can import folded enzymes, and they seem to lack intraperoxisomal chaperones. Here, we propose a mechanistic model for the early steps in peroxisomal-matrix-enzyme import, which might help to explain the unusual features of this process.",

author = "Gould, {Stephen J.} and Collins, {Cynthia S.}",

note = "Funding Information: We thank P. Coulombe, C. Machamer, S. Michaelis, K. Sacksteder and D. Valle for their critical reading of the manuscript and insightful suggestions. We also thank S. South and E. Baumgart for use of the electron micrograph of Saccharomyces cerevisiae. The concepts for this perspective arose from S. J. G.{\textquoteright}s research that has been funded by the National Institutes of Health.",

year = "2002",

doi = "10.1038/nrm807",

language = "English (US)",

volume = "3",

pages = "382--389",

journal = "Nature Reviews Molecular Cell Biology",

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TY - JOUR

T1 - Peroxisomal-protein import

T2 - Is it really that complex?

AU - Gould, Stephen J.

AU - Collins, Cynthia S.

N1 - Funding Information: We thank P. Coulombe, C. Machamer, S. Michaelis, K. Sacksteder and D. Valle for their critical reading of the manuscript and insightful suggestions. We also thank S. South and E. Baumgart for use of the electron micrograph of Saccharomyces cerevisiae. The concepts for this perspective arose from S. J. G.’s research that has been funded by the National Institutes of Health.

PY - 2002

Y1 - 2002

N2 - Peroxisomal enzymes are synthesized in the cytoplasm and imported post-translationally across the peroxisome membrane. Unlike other organelles with a sealed membrane, peroxisomes can import folded enzymes, and they seem to lack intraperoxisomal chaperones. Here, we propose a mechanistic model for the early steps in peroxisomal-matrix-enzyme import, which might help to explain the unusual features of this process.

AB - Peroxisomal enzymes are synthesized in the cytoplasm and imported post-translationally across the peroxisome membrane. Unlike other organelles with a sealed membrane, peroxisomes can import folded enzymes, and they seem to lack intraperoxisomal chaperones. Here, we propose a mechanistic model for the early steps in peroxisomal-matrix-enzyme import, which might help to explain the unusual features of this process.

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U2 - 10.1038/nrm807

DO - 10.1038/nrm807

M3 - Review article

C2 - 11988772

AN - SCOPUS:0036273592

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VL - 3

SP - 382

EP - 389

JO - Nature Reviews Molecular Cell Biology

JF - Nature Reviews Molecular Cell Biology

IS - 5

ER -

Peroxisomal-protein import: Is it really that complex?

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