Peroxisomal-protein import: Is it really that complex?

Stephen J. Gould, Cynthia S. Collins

Research output: Contribution to journalReview articlepeer-review

88 Scopus citations


Peroxisomal enzymes are synthesized in the cytoplasm and imported post-translationally across the peroxisome membrane. Unlike other organelles with a sealed membrane, peroxisomes can import folded enzymes, and they seem to lack intraperoxisomal chaperones. Here, we propose a mechanistic model for the early steps in peroxisomal-matrix-enzyme import, which might help to explain the unusual features of this process.

Original languageEnglish (US)
Pages (from-to)382-389
Number of pages8
JournalNature Reviews Molecular Cell Biology
Issue number5
StatePublished - 2002

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology


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