TY - JOUR
T1 - Peropsin, a novel visual pigment-like protein located in the apical microvilli of the retinal pigment epithelium
AU - Sun, Hui
AU - Gilbert, Debra J.
AU - Copeland, Neal G.
AU - Jenkins, Nancy A.
AU - Nathans, Jeremy
PY - 1997/9/2
Y1 - 1997/9/2
N2 - A visual pigment-like protein, referred to as peropsin, has been identified by large-scale sequencing of cDNAs derived from human ocular tissues. The corresponding mRNA was found only in the eye, where it is localized to the retinal pigment epithelium (RPE). Peropsin immunoreactivity, visualized by light and electron microscopy, localizes the protein to the apical face of the RPE, and most prominently to the microvilli that surround the photoreceptor outer segments. These observations suggest that peropsin may play a role in RPE physiology either by detecting light directly or by monitoring the concentration of retinoids or other photoreceptor-derived compounds.
AB - A visual pigment-like protein, referred to as peropsin, has been identified by large-scale sequencing of cDNAs derived from human ocular tissues. The corresponding mRNA was found only in the eye, where it is localized to the retinal pigment epithelium (RPE). Peropsin immunoreactivity, visualized by light and electron microscopy, localizes the protein to the apical face of the RPE, and most prominently to the microvilli that surround the photoreceptor outer segments. These observations suggest that peropsin may play a role in RPE physiology either by detecting light directly or by monitoring the concentration of retinoids or other photoreceptor-derived compounds.
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U2 - 10.1073/pnas.94.18.9893
DO - 10.1073/pnas.94.18.9893
M3 - Article
C2 - 9275222
AN - SCOPUS:0030886657
SN - 0027-8424
VL - 94
SP - 9893
EP - 9898
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 18
ER -