Peritrophic matrix proteins of Anopheles gambiae and Aedes aegypti

L. A. Moskalyk, M. M. Oo, M. Jacobs-Lorena

Research output: Contribution to journalArticlepeer-review

61 Scopus citations


Little is known about the composition and function of the mosquito peritrophic matrix (PM), a physical barrier that pathogens must traverse to complete their life cycles. Anopheles gambiae and Aedes aegypti PM proteins induced by blood or by a protein-free meal have been characterized by the use of 2-D gel electrophoresis and lectin-binding affinity assays. More than forty proteins have been identified in both species. Over half of the PM proteins of both mosquitoes migrate identically. Many PM proteins appear to be glycosylated, primarily by high mannose N-linked glycosyl groups.

Original languageEnglish (US)
Pages (from-to)261-268
Number of pages8
JournalInsect molecular biology
Issue number4
StatePublished - Jan 1 1996
Externally publishedYes


  • 2-D gels
  • Aedes
  • Anopheles
  • lectins
  • peritrophic matrix

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Insect Science


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