Abstract
Herein, we define peripheral arterial disease (PAD) as a significant obstructive atherosclerosis in the arterial system of the lower extremities. Representative clinical manifestations of PAD include intermittent claudication and tissue loss of the feet or toes. Both are typically due to the extensive accumulation of atherosclerotic plaques that lead to tissue ischemia and, in the case of tissue loss, potentially necrosis. In some cases, arterial revascularization is performed to restore adequate oxygen supply distal to the obstruction.
Original language | English (US) |
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Title of host publication | Encyclopedia of Cardiovascular Research and Medicine |
Publisher | Elsevier |
Pages | 49-59 |
Number of pages | 11 |
Volume | 1-4 |
ISBN (Electronic) | 9780128051542 |
ISBN (Print) | 9780128096574 |
DOIs | |
State | Published - Jan 1 2017 |
Externally published | Yes |
Keywords
- Ankle-brachial index
- Critical limb ischemia
- Peripheral arterial disease
ASJC Scopus subject areas
- General Medicine