Perioperative CT angiography assessment of locally advanced distal pancreatic carcinoma to evaluate feasibility of the modified Appleby procedure

Ayushi P. Gupta, Satomi Kawamoto, Ammar A. Javed, Matthew J. Weiss, Christopher L. Wolfgang, Jin He, Elliot K. Fishman, Harshna V. Vadvala

Research output: Contribution to journalArticlepeer-review


Purpose: To study the perioperative CT angiography (CTA) findings of modified Appleby procedure candidates for the surgical feasibility in patients with locally advanced distal pancreatic cancer (LAPC) and to assess CTA performance. Materials and methods: This retrospective study evaluated CTA of patients with distal LAPC who underwent modified Appleby procedure between March 2004 and October 2017. Preoperative CT scans performed within up to three months prior to the surgery and postoperative scans, at least one of which was within one month of surgery, were reviewed. Data was collected reporting tumor size, relation to vessels, changes from neoadjuvant chemoradiation, modifications to the surgery and complications. The CTA findings were correlated with operative notes and surgical pathology. Statistical analysis was performed using binary classification method to evaluate CTA performance. Results: Consecutive 20 patients underwent modified Appleby procedure in the study period. In 18/20 patients who received neoadjuvant chemoradiation, mean pancreatic mass size significantly reduced from 4.58 + 1.17 cm to 3.55 + 0.84 cm (p = 0.002). The celiac axis (CA) was encased in all, whereas none of the patients had encasement of the superior mesenteric artery (SMA) or involvement of gastroduodenal artery (GDA). The CTA had 88.89 % sensitivity, 100 % specificity, and 90 % accuracy for evaluating the arterial involvement. Conclusion: Distal LAPC patients, in particular those who have significant size reduction after neoadjuvant chemoradiation, with encasement of CA and without encasement of SMA and GDA can undergo a technically successful modified Appleby procedure. CTA offers accurate and valuable perioperative assessment of the surgical candidates.

Original languageEnglish (US)
Article number109248
JournalEuropean Journal of Radiology
StatePublished - Oct 2020


  • CT angiography
  • Distal pancreatectomy
  • Locally advanced pancreatic carcinoma and neoadjuvant chemoradiation
  • Modified Appleby procedure
  • Pancreatic adenocarcinoma

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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