Perioperative care of the patient with a periodic fever syndrome

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Periodic fever syndromes are autoinflammatory disorders associated with recurrent fevers unrelated to infection. Little is known about the perioperative management of patients with these syndromes, and existing literature consists primarily of case reports and occasional case series. This narrative review discusses background information and diagnostic criteria for the three most common periodic fever syndromes: periodic fever, aphthous stomatitis, pharyngitis, adenitis (PFAPA), familial Mediterranean fever (FMF), and TNF receptor-associated periodic syndrome (TRAPS), and describes perioperative considerations for anesthesia providers when caring for the patient with a periodic fever syndrome. We include a systems-based framework in which to organize these considerations.

Original languageEnglish (US)
Article number111497
JournalJournal of Clinical Anesthesia
StatePublished - Sep 2024


  • Anesthesia
  • Hereditary autoinflammatory diseases
  • Perioperative care
  • fever

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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