Periocular Histiocytoid Carcinoma: Potential Diagnostic Challenges

Joseph R. Yates, Michael J. Mines, Prem Subramanian, Roxana Rivera-Michlig, Thomas J. Cummings, Charles G. Eberhart

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Cutaneous histiocytoid carcinoma can occur as a primary tumor of the periocular region. Morphologically similar histiocytoid carcinomas arising as primary tumors of the breast have a predilection for orbital metastases. They can occasionally contain regions with prominent vacuolated cytoplasm and minimal nuclear atypia, which mimic benign histiocytic lesions. Differentiating nonneoplastic, primary neoplastic, and metastatic histiocytoid lesions involving the periorbita can be challenging for both the clinician and the pathologist, and this distinction has management implications. Herein, we present 3 cases to illustrate the challenges of diagnosing periocular histiocytoid carcinoma.

Original languageEnglish (US)
Pages (from-to)94-101
Number of pages8
JournalOcular Oncology and Pathology
Issue number2
StatePublished - Feb 1 2019


  • Eyelid
  • Histiocytoid carcinoma
  • Metastasis
  • Orbit
  • Signet-ring cell carcinoma

ASJC Scopus subject areas

  • Nursing(all)


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