TY - JOUR
T1 - Perinatal biomarkers in prematurity
T2 - Early identification of neurologic injury
AU - Andrikopoulou, Maria
AU - Almalki, Ahmad
AU - Farzin, Azadeh
AU - Cordeiro, Christina N.
AU - Johnston, Michael V.
AU - Burd, Irina
N1 - Funding Information:
This work was supported by NICHDK08HD073315 (I.B.) and NINDSNS28208 (M.J.).
PY - 2014/8
Y1 - 2014/8
N2 - Over the past few decades, biomarkers have become increasingly utilized as non-invasive tools in the early diagnosis and management of various clinical conditions. In perinatal medicine, the improved survival of extremely premature infants who are at high risk for adverse neurologic outcomes has increased the demand for the discovery of biomarkers in detecting and predicting the prognosis of infants with neonatal brain injury. By enabling the clinician to recognize potential brain damage early, biomarkers could allow clinicians to intervene at the early stages of disease, and to monitor the efficacy of those interventions. This review will first examine the potential perinatal biomarkers for neurologic complications of prematurity, specifically, intraventricular hemorrhage (IVH), periventricular leukomalacia (PVL) and posthemorrhagic hydrocephalus (PHH). It will also evaluate knowledge gained from animal models regarding the pathogenesis of perinatal brain injury in prematurity.
AB - Over the past few decades, biomarkers have become increasingly utilized as non-invasive tools in the early diagnosis and management of various clinical conditions. In perinatal medicine, the improved survival of extremely premature infants who are at high risk for adverse neurologic outcomes has increased the demand for the discovery of biomarkers in detecting and predicting the prognosis of infants with neonatal brain injury. By enabling the clinician to recognize potential brain damage early, biomarkers could allow clinicians to intervene at the early stages of disease, and to monitor the efficacy of those interventions. This review will first examine the potential perinatal biomarkers for neurologic complications of prematurity, specifically, intraventricular hemorrhage (IVH), periventricular leukomalacia (PVL) and posthemorrhagic hydrocephalus (PHH). It will also evaluate knowledge gained from animal models regarding the pathogenesis of perinatal brain injury in prematurity.
KW - Biomarkers
KW - Brain injury
KW - Intraventricular hemorrhage
KW - Periventricular leukomalacia
KW - Prematurity
UR - http://www.scopus.com/inward/record.url?scp=84901604247&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84901604247&partnerID=8YFLogxK
U2 - 10.1016/j.ijdevneu.2014.04.002
DO - 10.1016/j.ijdevneu.2014.04.002
M3 - Review article
C2 - 24768951
AN - SCOPUS:84901604247
SN - 0736-5748
VL - 36
SP - 25
EP - 31
JO - International Journal of Developmental Neuroscience
JF - International Journal of Developmental Neuroscience
ER -