Perfusion-weighted magnetic resonance imaging of the brain: Techniques and application in children

Thierry A G M Huisman, A. Gregory Sorensen

Research output: Contribution to journalArticlepeer-review

51 Scopus citations


Perfusion-weighted magnetic resonance imaging (PWI) has been proposed as an attractive non-invasive tool for evaluating cerebral haemodynamics. Quantitative maps of cerebral blood flow (CBF), cerebral blood volume (CBV), mean transit time (MTT), time to peak (TTP) and various other haemodynamic parameters can be obtained. Recent advances in hard- and software made PWI available for clinical routine. Although PWI became common in adult neuroradiology, it remains challenging in pediatric neuroradiology. In this article, the different PWI techniques that render haemodynamic maps of the brain are presented and discussed. The normal developmental changes of the cerebral haemodynamics in children as measured by PWI are presented as well as the application of PWI in cerebral ischaemia, primary and secondary cerebral vasculopathies and in cerebral tumours.

Original languageEnglish (US)
Pages (from-to)59-72
Number of pages14
JournalEuropean Radiology
Issue number1
StatePublished - Jan 2004
Externally publishedYes


  • Dynamic suceptibility contrast imaging
  • Haemodynamic parameter children
  • Perfusion-weighted imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology


Dive into the research topics of 'Perfusion-weighted magnetic resonance imaging of the brain: Techniques and application in children'. Together they form a unique fingerprint.

Cite this