Perfusion Damage to Renal Allografts

Donald R. Steinmuller; Charles P. Tifft; John J. Curtis; Dinyar Bhathena; Bruce A. Lucas; J. William Mcroberts; Robert G. Luke; David Spector; Catherine Limas; James L. Frost; James B. Zachary; Sylvester Sterioff; G. Melville Williams; Ronald T. Rolley; John H. Sadler

doi:10.1056/NEJM197705262962115

Perfusion Damage to Renal Allografts

Donald R. Steinmuller, Charles P. Tifft, John J. Curtis, Dinyar Bhathena, Bruce A. Lucas, J. William Mcroberts, Robert G. Luke, David Spector, Catherine Limas, James L. Frost, James B. Zachary, Sylvester Sterioff, G. Melville Williams, Ronald T. Rolley, John H. Sadler

Research output: Contribution to journal › Letter › peer-review

7 Scopus citations

Abstract

To the Editor: The perfusion nephropathy in human transplants described by Spector et al. (N Engl J Med 295:1217–1221, 1976) is morphologically very similar to the glomerular lesion attributed to steroids in canine homografts and autografts.¹^,² Both have diffuse eosinophilic material within glomerular loops and a similar appearance on light microscopy at one to two hours. Since methylprednisolone (120 mg) was added to the perfusate in all the perfused donor kidneys reported by Spector and his colleagues, it is possible that this agent was responsible for the pathologic lesion and the decreased graft survival. The dose of methylprednisolone in.

Original language	English (US)
Pages (from-to)	1232-1233
Number of pages	2
Journal	New England Journal of Medicine
Volume	296
Issue number	21
DOIs	https://doi.org/10.1056/NEJM197705262962115
State	Published - May 26 1977
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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@article{9e352a31738b497dbc9cd6da6e72a848,

title = "Perfusion Damage to Renal Allografts",

abstract = "To the Editor: The perfusion nephropathy in human transplants described by Spector et al. (N Engl J Med 295:1217–1221, 1976) is morphologically very similar to the glomerular lesion attributed to steroids in canine homografts and autografts.1,2 Both have diffuse eosinophilic material within glomerular loops and a similar appearance on light microscopy at one to two hours. Since methylprednisolone (120 mg) was added to the perfusate in all the perfused donor kidneys reported by Spector and his colleagues, it is possible that this agent was responsible for the pathologic lesion and the decreased graft survival. The dose of methylprednisolone in.",

author = "Steinmuller, {Donald R.} and Tifft, {Charles P.} and Curtis, {John J.} and Dinyar Bhathena and Lucas, {Bruce A.} and Mcroberts, {J. William} and Luke, {Robert G.} and David Spector and Catherine Limas and Frost, {James L.} and Zachary, {James B.} and Sylvester Sterioff and Williams, {G. Melville} and Rolley, {Ronald T.} and Sadler, {John H.}",

year = "1977",

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doi = "10.1056/NEJM197705262962115",

language = "English (US)",

volume = "296",

pages = "1232--1233",

journal = "New England Journal of Medicine",

issn = "0028-4793",

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TY - JOUR

T1 - Perfusion Damage to Renal Allografts

AU - Steinmuller, Donald R.

AU - Tifft, Charles P.

AU - Curtis, John J.

AU - Bhathena, Dinyar

AU - Lucas, Bruce A.

AU - Mcroberts, J. William

AU - Luke, Robert G.

AU - Spector, David

AU - Limas, Catherine

AU - Frost, James L.

AU - Zachary, James B.

AU - Sterioff, Sylvester

AU - Williams, G. Melville

AU - Rolley, Ronald T.

AU - Sadler, John H.

PY - 1977/5/26

Y1 - 1977/5/26

N2 - To the Editor: The perfusion nephropathy in human transplants described by Spector et al. (N Engl J Med 295:1217–1221, 1976) is morphologically very similar to the glomerular lesion attributed to steroids in canine homografts and autografts.1,2 Both have diffuse eosinophilic material within glomerular loops and a similar appearance on light microscopy at one to two hours. Since methylprednisolone (120 mg) was added to the perfusate in all the perfused donor kidneys reported by Spector and his colleagues, it is possible that this agent was responsible for the pathologic lesion and the decreased graft survival. The dose of methylprednisolone in.

AB - To the Editor: The perfusion nephropathy in human transplants described by Spector et al. (N Engl J Med 295:1217–1221, 1976) is morphologically very similar to the glomerular lesion attributed to steroids in canine homografts and autografts.1,2 Both have diffuse eosinophilic material within glomerular loops and a similar appearance on light microscopy at one to two hours. Since methylprednisolone (120 mg) was added to the perfusate in all the perfused donor kidneys reported by Spector and his colleagues, it is possible that this agent was responsible for the pathologic lesion and the decreased graft survival. The dose of methylprednisolone in.

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DO - 10.1056/NEJM197705262962115

M3 - Letter

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SN - 0028-4793

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SP - 1232

EP - 1233

JO - New England Journal of Medicine

JF - New England Journal of Medicine

IS - 21

ER -

Perfusion Damage to Renal Allografts

Abstract

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