TY - JOUR
T1 - Performance characteristics and comparison of two fecal occult blood tests in patients undergoing colonoscopy
AU - Cruz-Correa, Marcia
AU - Schultz, Kathleen
AU - Jagannath, Sanjay
AU - Harris, Mary
AU - Kantsevoy, Sergey
AU - Bedine, Marshall
AU - Kalloo, Anthony N.
N1 - Funding Information:
Acknowledgments This work was supported by Grant K07 CA092445 (to M.C.C.) and supported in part by an unrestricted grant from the Sol Hubert Trust (supplied EZ-Detect packages). None of the authors are on the Advisory Boards or Speaker Bureaus for the Sol Hubert Trust.
PY - 2007/4
Y1 - 2007/4
N2 - We investigated the use of a new type of FOBT (EZ-Detect) that uses the blood's pseudo-peroxidase activity as an enzymatic catalyst, in a one-step chromogen-substrate system performed by the patient. Asymptomatic patients ≤50 years old received three Hemoccult II (HO) cards and three EZ-Detect (EZ) packages to be used in three consecutive bowel movements. Sensitivity, specificity, positive predictive value, and negative predictive value for detection of colorectal neoplasia was calculated. The study included 207 patients, with a mean age of 58.9 years. Diagnostic accuracy for detection of adenomas was similar for the EZ and HO tests (66.7% vs. 71.0%; P=0.48), while for advanced adenomas diagnostic accuracy for the EZ and HO tests was 86.0% vs. 94.2% (P=0.01), respectively. Most patients preferred the EZ test (92% vs. 8%). We conclude that the EZ test has a diagnostic profile similar to that of the HO test for identification of adenomas; however, for advanced adenomas the diagnostic accuracy was slightly better for the HO. The EZ test was preferred by most patients, which may increase colorectal cancer screening compliance.
AB - We investigated the use of a new type of FOBT (EZ-Detect) that uses the blood's pseudo-peroxidase activity as an enzymatic catalyst, in a one-step chromogen-substrate system performed by the patient. Asymptomatic patients ≤50 years old received three Hemoccult II (HO) cards and three EZ-Detect (EZ) packages to be used in three consecutive bowel movements. Sensitivity, specificity, positive predictive value, and negative predictive value for detection of colorectal neoplasia was calculated. The study included 207 patients, with a mean age of 58.9 years. Diagnostic accuracy for detection of adenomas was similar for the EZ and HO tests (66.7% vs. 71.0%; P=0.48), while for advanced adenomas diagnostic accuracy for the EZ and HO tests was 86.0% vs. 94.2% (P=0.01), respectively. Most patients preferred the EZ test (92% vs. 8%). We conclude that the EZ test has a diagnostic profile similar to that of the HO test for identification of adenomas; however, for advanced adenomas the diagnostic accuracy was slightly better for the HO. The EZ test was preferred by most patients, which may increase colorectal cancer screening compliance.
KW - Colorectal cancer
KW - Diagnostic accuracy
KW - Fecal occult blood testing
KW - Screening
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U2 - 10.1007/s10620-006-9383-y
DO - 10.1007/s10620-006-9383-y
M3 - Article
C2 - 17380401
AN - SCOPUS:33947593115
SN - 0163-2116
VL - 52
SP - 1009
EP - 1013
JO - Digestive diseases and sciences
JF - Digestive diseases and sciences
IS - 4
ER -