TY - JOUR
T1 - Percutaneous US-Guided Implantation of Vx-2 Carcinoma into Rabbit Liver
T2 - A Comparison With Open Surgical Method
AU - Lee, Kwang Hun
AU - Liapi, Eleni
AU - Buijs, Manon
AU - Anna Vossen, Josephina
AU - Prieto-Ventura, Veronica
AU - Syed, Labiq H.
AU - Geschwind, Jean Francois H.
PY - 2009/7
Y1 - 2009/7
N2 - Purpose: To evaluate technical feasibility and experimental usefulness of percutaneous US-guided implantation of Vx-2 carcinoma in rabbit liver. Materials and Methods: Forty-eight New Zealand White male rabbits were used. Solid tumor mass of Vx-2 carcinoma was harvested from carrier rabbit, and minced tumor cells were implanted. Twenty-four rabbits underwent percutaneous US-guided tumor implantation, and the same number of rabbits underwent open laparotomy tumor implantation. Tested parameters included technical success, procedural time, amount of anesthesia, recovery time, complications, tumor size, and regional tumor seeding. Results: A new percutaneous US-guided implantation was technically feasible in all rabbits. Evaluation parameters showed that the percutaneous US-guided implantation method is less invasive than the open laparotomy method. Targeting rate for left lateral lobe of implantation site was comparable in both methods (91.7% of percutaneous US-guided; 95.8% in open laparotomy). The success rate of tumor growth in the liver was 100% in both groups. However, in the group with US-guidance, tumor seeding developed more frequently in five of 24 rabbits (20.8%) than in open laparotomy group (2/24, 8.3%). Five rabbits had thoracoabdominal wall needle tract seeding, and two rabbits had tumor seeding at both thoracoabdominal wall and intraperitoneal space. Conclusions: Percutaneous US-guided implantation of Vx-2 carcinoma in rabbit liver is a less invasive alternative to open laparotomy, achieving equally successful tumor growth in the liver. Although percutaneous US-guidance implantation method may not be considered for long-term survival study design because of the possibility of tumor seeding, it can be considered for nonsurvival study design.
AB - Purpose: To evaluate technical feasibility and experimental usefulness of percutaneous US-guided implantation of Vx-2 carcinoma in rabbit liver. Materials and Methods: Forty-eight New Zealand White male rabbits were used. Solid tumor mass of Vx-2 carcinoma was harvested from carrier rabbit, and minced tumor cells were implanted. Twenty-four rabbits underwent percutaneous US-guided tumor implantation, and the same number of rabbits underwent open laparotomy tumor implantation. Tested parameters included technical success, procedural time, amount of anesthesia, recovery time, complications, tumor size, and regional tumor seeding. Results: A new percutaneous US-guided implantation was technically feasible in all rabbits. Evaluation parameters showed that the percutaneous US-guided implantation method is less invasive than the open laparotomy method. Targeting rate for left lateral lobe of implantation site was comparable in both methods (91.7% of percutaneous US-guided; 95.8% in open laparotomy). The success rate of tumor growth in the liver was 100% in both groups. However, in the group with US-guidance, tumor seeding developed more frequently in five of 24 rabbits (20.8%) than in open laparotomy group (2/24, 8.3%). Five rabbits had thoracoabdominal wall needle tract seeding, and two rabbits had tumor seeding at both thoracoabdominal wall and intraperitoneal space. Conclusions: Percutaneous US-guided implantation of Vx-2 carcinoma in rabbit liver is a less invasive alternative to open laparotomy, achieving equally successful tumor growth in the liver. Although percutaneous US-guidance implantation method may not be considered for long-term survival study design because of the possibility of tumor seeding, it can be considered for nonsurvival study design.
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U2 - 10.1016/j.jss.2008.08.036
DO - 10.1016/j.jss.2008.08.036
M3 - Article
C2 - 19181344
AN - SCOPUS:67349150419
SN - 0022-4804
VL - 155
SP - 94
EP - 99
JO - Journal of Surgical Research
JF - Journal of Surgical Research
IS - 1
ER -