TY - JOUR
T1 - Percent fat mass is inversely associated with bone mass and hip geometry in rural Chinese adolescents
AU - Hong, Xiumei
AU - Arguelles, Lester M.
AU - Liu, Xin
AU - Tsai, Hui Ju
AU - Hsu, Yi Hsiang
AU - Wang, Binyan
AU - Zhang, Shanchun
AU - Li, Zhiping
AU - Tang, Gengfu
AU - Liu, Xue
AU - Yang, Jianhua
AU - Xu, Xiping
AU - Langman, Craig
AU - Wang, Xiaobin
PY - 2010/7
Y1 - 2010/7
N2 - This study was an attempt to examine the phenotypic, genetic, and environmental correlations between percent fat mass (PFM) and bone parameters, especially hip geometry, among 786 males and 618 females aged 13 to 21 years from a Chinese twin cohort. PFM, bone area (BA), bone mineral content (BMC), cross-sectional area (CSA), and section modulus (SM) were obtained by dual-energy X-ray absorptiometry. Multiple linear regression models were used to assess the PFM-bone relationships. A structural equation model for twin design was used to estimate genetic/environmental influences on individual phenotype and phenotypic correlations. After controlling for body weight and other pertinent covariates, we observed inverse associations between PFM and bone parameters: Compared with the lowest age- and gender-specific tertile of PFM, males in the highest tertile of PFM had lower measures of whole-body-less-head BA (WB-BA), lumbar spine BA (L2-L4-BA), total-hip BA (TH-BA), total-hip BMC, CSA, and SM (p<.005 for all, adjusted p<.05). Similar inverse associations were observed in females for all the preceding parameters except WB-BA and L2-L4-BA. These associations did not vary significantly by Tanner stages. In both genders, the estimated heritabilities were 80% to 86% for BMC, 67% to 80% for BA, 74% to 77% for CSA, and 64% for SM. Both shared genetics and environmental factors contributed to the inverse PFM-bone correlations. We conclude that in this sample of relatively lean Chinese adolescents, at a given body weight, PFM is inversely associated with BA, BMC, and hip geometry in both genders, and such associations are attributed to both shared genetic and environmental factors.
AB - This study was an attempt to examine the phenotypic, genetic, and environmental correlations between percent fat mass (PFM) and bone parameters, especially hip geometry, among 786 males and 618 females aged 13 to 21 years from a Chinese twin cohort. PFM, bone area (BA), bone mineral content (BMC), cross-sectional area (CSA), and section modulus (SM) were obtained by dual-energy X-ray absorptiometry. Multiple linear regression models were used to assess the PFM-bone relationships. A structural equation model for twin design was used to estimate genetic/environmental influences on individual phenotype and phenotypic correlations. After controlling for body weight and other pertinent covariates, we observed inverse associations between PFM and bone parameters: Compared with the lowest age- and gender-specific tertile of PFM, males in the highest tertile of PFM had lower measures of whole-body-less-head BA (WB-BA), lumbar spine BA (L2-L4-BA), total-hip BA (TH-BA), total-hip BMC, CSA, and SM (p<.005 for all, adjusted p<.05). Similar inverse associations were observed in females for all the preceding parameters except WB-BA and L2-L4-BA. These associations did not vary significantly by Tanner stages. In both genders, the estimated heritabilities were 80% to 86% for BMC, 67% to 80% for BA, 74% to 77% for CSA, and 64% for SM. Both shared genetics and environmental factors contributed to the inverse PFM-bone correlations. We conclude that in this sample of relatively lean Chinese adolescents, at a given body weight, PFM is inversely associated with BA, BMC, and hip geometry in both genders, and such associations are attributed to both shared genetic and environmental factors.
KW - Adolescence
KW - Bone mineral content
KW - Coheritability
KW - Hip geometry
KW - Percent fat mass
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U2 - 10.1002/jbmr.40
DO - 10.1002/jbmr.40
M3 - Article
C2 - 20200956
AN - SCOPUS:77954727537
SN - 0884-0431
VL - 25
SP - 1544
EP - 1554
JO - Journal of Bone and Mineral Research
JF - Journal of Bone and Mineral Research
IS - 7
ER -