Peptidyl-prolyl isomerases: A full cast of critical actors in cardiovascular diseases

Gianluca Lorenzo Perrucci; Aoife Gowran; Marco Zanobini; Maurizio Colognesi Capogrossi; Giulio Pompilio; Patrizia Nigro

doi:10.1093/cvr/cvv096

Peptidyl-prolyl isomerases: A full cast of critical actors in cardiovascular diseases

Gianluca Lorenzo Perrucci, Aoife Gowran, Marco Zanobini, Maurizio Colognesi Capogrossi, Giulio Pompilio, Patrizia Nigro

Research output: Contribution to journal › Review article › peer-review

Abstract

Peptidyl-prolyl cis-trans-isomerases are a highly conserved family of immunophilins. The three peptidyl-prolyl cis-trans-isomerase subfamilies are cyclophilins, FK-506-binding proteins, and parvulins. Peptidyl-prolyl cis-trans-isomerases are expressed in multiple human tissues and regulate different cellular functions, e.g. calcium handling, protein folding, and gene expression. Moreover, these subfamilies have been shown to be consistently involved in several cardiac and vascular diseases including heart failure, arrhythmias, vascular stenosis, endothelial dysfunction, atherosclerosis, and hypertension. This review provides a concise description of the peptidyl-prolyl cis-trans-isomerases and presents an incisive selection of studies focused on their relationship with cardiovascular diseases.

Original language	English (US)
Pages (from-to)	353-364
Number of pages	12
Journal	Cardiovascular research
Volume	106
Issue number	3
DOIs	https://doi.org/10.1093/cvr/cvv096
State	Published - Jun 1 2015
Externally published	Yes

Keywords

Cardiovascular disease
Cyclophilins
FKBPs
Parvulins

ASJC Scopus subject areas

Physiology
Cardiology and Cardiovascular Medicine
Physiology (medical)

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10.1093/cvr/cvv096

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title = "Peptidyl-prolyl isomerases: A full cast of critical actors in cardiovascular diseases",

abstract = "Peptidyl-prolyl cis-trans-isomerases are a highly conserved family of immunophilins. The three peptidyl-prolyl cis-trans-isomerase subfamilies are cyclophilins, FK-506-binding proteins, and parvulins. Peptidyl-prolyl cis-trans-isomerases are expressed in multiple human tissues and regulate different cellular functions, e.g. calcium handling, protein folding, and gene expression. Moreover, these subfamilies have been shown to be consistently involved in several cardiac and vascular diseases including heart failure, arrhythmias, vascular stenosis, endothelial dysfunction, atherosclerosis, and hypertension. This review provides a concise description of the peptidyl-prolyl cis-trans-isomerases and presents an incisive selection of studies focused on their relationship with cardiovascular diseases.",

keywords = "Cardiovascular disease, Cyclophilins, FKBPs, Parvulins",

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year = "2015",

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doi = "10.1093/cvr/cvv096",

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T2 - A full cast of critical actors in cardiovascular diseases

AU - Perrucci, Gianluca Lorenzo

AU - Gowran, Aoife

AU - Zanobini, Marco

AU - Capogrossi, Maurizio Colognesi

AU - Pompilio, Giulio

AU - Nigro, Patrizia

PY - 2015/6/1

Y1 - 2015/6/1

N2 - Peptidyl-prolyl cis-trans-isomerases are a highly conserved family of immunophilins. The three peptidyl-prolyl cis-trans-isomerase subfamilies are cyclophilins, FK-506-binding proteins, and parvulins. Peptidyl-prolyl cis-trans-isomerases are expressed in multiple human tissues and regulate different cellular functions, e.g. calcium handling, protein folding, and gene expression. Moreover, these subfamilies have been shown to be consistently involved in several cardiac and vascular diseases including heart failure, arrhythmias, vascular stenosis, endothelial dysfunction, atherosclerosis, and hypertension. This review provides a concise description of the peptidyl-prolyl cis-trans-isomerases and presents an incisive selection of studies focused on their relationship with cardiovascular diseases.

AB - Peptidyl-prolyl cis-trans-isomerases are a highly conserved family of immunophilins. The three peptidyl-prolyl cis-trans-isomerase subfamilies are cyclophilins, FK-506-binding proteins, and parvulins. Peptidyl-prolyl cis-trans-isomerases are expressed in multiple human tissues and regulate different cellular functions, e.g. calcium handling, protein folding, and gene expression. Moreover, these subfamilies have been shown to be consistently involved in several cardiac and vascular diseases including heart failure, arrhythmias, vascular stenosis, endothelial dysfunction, atherosclerosis, and hypertension. This review provides a concise description of the peptidyl-prolyl cis-trans-isomerases and presents an incisive selection of studies focused on their relationship with cardiovascular diseases.

KW - Cardiovascular disease

KW - Cyclophilins

KW - FKBPs

KW - Parvulins

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Peptidyl-prolyl isomerases: A full cast of critical actors in cardiovascular diseases

Abstract

Keywords

ASJC Scopus subject areas

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