Peptidyl-prolyl isomerases: A full cast of critical actors in cardiovascular diseases

Gianluca Lorenzo Perrucci, Aoife Gowran, Marco Zanobini, Maurizio Colognesi Capogrossi, Giulio Pompilio, Patrizia Nigro

Research output: Contribution to journalReview articlepeer-review


Peptidyl-prolyl cis-trans-isomerases are a highly conserved family of immunophilins. The three peptidyl-prolyl cis-trans-isomerase subfamilies are cyclophilins, FK-506-binding proteins, and parvulins. Peptidyl-prolyl cis-trans-isomerases are expressed in multiple human tissues and regulate different cellular functions, e.g. calcium handling, protein folding, and gene expression. Moreover, these subfamilies have been shown to be consistently involved in several cardiac and vascular diseases including heart failure, arrhythmias, vascular stenosis, endothelial dysfunction, atherosclerosis, and hypertension. This review provides a concise description of the peptidyl-prolyl cis-trans-isomerases and presents an incisive selection of studies focused on their relationship with cardiovascular diseases.

Original languageEnglish (US)
Pages (from-to)353-364
Number of pages12
JournalCardiovascular research
Issue number3
StatePublished - Jun 1 2015
Externally publishedYes


  • Cardiovascular disease
  • Cyclophilins
  • FKBPs
  • Parvulins

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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