Peptidomimetic competitive inhibitors of protein tyrosine phosphatases

Kui Shen, Lixin Qi, Lynn Stiff

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


This review discusses the development of the active site-directed protein tyrosine phosphatase (PTP) inhibitors based on peptides and some closely related nonpeptidic scaffolds. A straightforward approach is to substitute various nonhydrolyzable analogs for the phosphotyrosine (pTyr) of optimal or physiological phosphopeptide substrates of PTPs. The advances in small molecule peptidic PTP inhibitors and their nonpeptidic derivatives have been greatly aided by X-ray crystallographic and NMR spectrometric studies. Given the importance of PTPs in disease-associated signal transduction and the continuing progress in PTP drug discovery, some clinically useful PTP inhibitors may emerge in the near future.

Original languageEnglish (US)
Pages (from-to)3101-3117
Number of pages17
JournalCurrent Pharmaceutical Design
Issue number28
StatePublished - 2010
Externally publishedYes


  • Activity-based probe
  • Peptidomimetic competitive inhibitor
  • Phosphopeptide substrate
  • Phosphotyrosine analog
  • Protein tyrosine phosphatase inhibitor
  • Substrate trapping mutant

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology


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