Peptide Leukotriene Release after Antigen Challenge in Patients Sensitive to Ragweed

Peter S. Creticos, Stephen P. Peters, N. Franklin Adkinson, Robert M. Naclerio, Edward C. Hayes, Philip S. Norman, Lawrence M. Lichtenstein

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297 Scopus citations


Slow-reacting substance of anaphylaxis (composed of leukotrienes C, D, and E) is released in vitro by the interaction of antigen and IgE antibody on human mast cells and basophils. When we challenged ragweed-sensitive patients intranasally with pollen grains, their clinical response was significantly correlated with the release of the peptide leukotrienes (P<0.001). Nonallergic subjects had neither symptoms nor leukotriene release. The leukotrienes were released in a dose-dependent fashion, with a peak mean level of 827±234 pg per 0.1 ml of a 10-ml nasal wash. High-performance liquid chromatography revealed the presence of leukotrienes C, D, and E, suggesting that nasal cells or fluids had the ability to degrade leukotriene C enzymatically. The in vivo release of these potent inflammatory mediators after exposure to pollen suggests that leukotrienes may have an important role in human allergic reactions. (N Engl J Med 1984; 310:1626–30.).

Original languageEnglish (US)
Pages (from-to)1626-1630
Number of pages5
JournalNew England Journal of Medicine
Issue number25
StatePublished - Jun 21 1984

ASJC Scopus subject areas

  • Medicine(all)


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