People with schizophrenia and depression have a low omega-3 index

Natalie Parletta; Dorota Zarnowiecki; Jihyun Cho; Amy Wilson; Nicholas Procter; Andrea Gordon; Svetlana Bogomolova; Kerin O'Dea; John Strachan; Matt Ballestrin; Andrew Champion; Barbara J. Meyer

doi:10.1016/j.plefa.2016.05.007

People with schizophrenia and depression have a low omega-3 index

Natalie Parletta, Dorota Zarnowiecki, Jihyun Cho, Amy Wilson, Nicholas Procter, Andrea Gordon, Svetlana Bogomolova, Kerin O'Dea, John Strachan, Matt Ballestrin, Andrew Champion, Barbara J. Meyer

School of Nursing

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Cardiovascular disease (CVD) is higher in people with mental illness and is associated with a 30 year higher mortality rate in this population. Erythrocyte docosahexaenoic acid (DHA) plus eicosapentaenoic acid (EPA) (omega-3 index)≤4% is a marker for increased mortality risk from CVD while >8% is protective. Omega-3 polyunsaturated fatty acids are also important for brain function and may ameliorate symptoms of mental illness. We investigated the erythrocyte omega-3 index in people with mental illness. One hundred and thirty adults aged 18-65 years (32.6% male) with schizophrenia (n=14) and depression (n=116) provided blood samples and completed physiological assessments and questionnaires. Both populations had risk factors for metabolic syndrome and CVD. The average omega-3 index was 3.95% (SD=1.06), compared to an estimated 5% in the Australian population. These data indicate an unfavourable omega-3 profile in people with mental illness that could contribute to higher CVD risk.

Original language	English (US)
Pages (from-to)	42-47
Number of pages	6
Journal	Prostaglandins Leukotrienes and Essential Fatty Acids
Volume	110
DOIs	https://doi.org/10.1016/j.plefa.2016.05.007
State	Published - Jul 1 2016

Keywords

Cardiovascular disease
Depression
Mental illness
Omega-3
Omega-3 index
Polyunsaturated fatty acids
Schizophrenia

ASJC Scopus subject areas

Clinical Biochemistry
Cell Biology

Access to Document

10.1016/j.plefa.2016.05.007

Cite this

@article{93b7ba6bca6c411fabef3531706a602a,

title = "People with schizophrenia and depression have a low omega-3 index",

abstract = "Cardiovascular disease (CVD) is higher in people with mental illness and is associated with a 30 year higher mortality rate in this population. Erythrocyte docosahexaenoic acid (DHA) plus eicosapentaenoic acid (EPA) (omega-3 index)≤4% is a marker for increased mortality risk from CVD while >8% is protective. Omega-3 polyunsaturated fatty acids are also important for brain function and may ameliorate symptoms of mental illness. We investigated the erythrocyte omega-3 index in people with mental illness. One hundred and thirty adults aged 18-65 years (32.6% male) with schizophrenia (n=14) and depression (n=116) provided blood samples and completed physiological assessments and questionnaires. Both populations had risk factors for metabolic syndrome and CVD. The average omega-3 index was 3.95% (SD=1.06), compared to an estimated 5% in the Australian population. These data indicate an unfavourable omega-3 profile in people with mental illness that could contribute to higher CVD risk.",

keywords = "Cardiovascular disease, Depression, Mental illness, Omega-3, Omega-3 index, Polyunsaturated fatty acids, Schizophrenia",

author = "Natalie Parletta and Dorota Zarnowiecki and Jihyun Cho and Amy Wilson and Nicholas Procter and Andrea Gordon and Svetlana Bogomolova and Kerin O'Dea and John Strachan and Matt Ballestrin and Andrew Champion and Meyer, {Barbara J.}",

note = "Funding Information: We acknowledge and thank the team at the TPC for their support of study 1 and assistance in obtaining blood samples from their consumers. We gratefully thank Louise Massie and the Sansom Health Clinic for support with clinic visits and administration associated with study 2, Lauren Roach for assistance with fatty analysis and all participants for taking part. NP (formerly Sinn), DZ and AW are supported by NHMRC (National Health and Medical Research Council) Program Grant funding ( # 320860 and 631947 ). Epax, Pathway International, Edgell, John West and Cobram Estate provided fish oil supplements, food and extra virgin olive oil for Study 2 from which these baseline data are derived. Publisher Copyright: {\textcopyright} 2016 Elsevier Ltd.",

year = "2016",

month = jul,

day = "1",

doi = "10.1016/j.plefa.2016.05.007",

language = "English (US)",

volume = "110",

pages = "42--47",

journal = "Prostaglandins Leukotrienes and Essential Fatty Acids",

issn = "0952-3278",

publisher = "Churchill Livingstone",

}

TY - JOUR

T1 - People with schizophrenia and depression have a low omega-3 index

AU - Parletta, Natalie

AU - Zarnowiecki, Dorota

AU - Cho, Jihyun

AU - Wilson, Amy

AU - Procter, Nicholas

AU - Gordon, Andrea

AU - Bogomolova, Svetlana

AU - O'Dea, Kerin

AU - Strachan, John

AU - Ballestrin, Matt

AU - Champion, Andrew

AU - Meyer, Barbara J.

N1 - Funding Information: We acknowledge and thank the team at the TPC for their support of study 1 and assistance in obtaining blood samples from their consumers. We gratefully thank Louise Massie and the Sansom Health Clinic for support with clinic visits and administration associated with study 2, Lauren Roach for assistance with fatty analysis and all participants for taking part. NP (formerly Sinn), DZ and AW are supported by NHMRC (National Health and Medical Research Council) Program Grant funding ( # 320860 and 631947 ). Epax, Pathway International, Edgell, John West and Cobram Estate provided fish oil supplements, food and extra virgin olive oil for Study 2 from which these baseline data are derived. Publisher Copyright: © 2016 Elsevier Ltd.

PY - 2016/7/1

Y1 - 2016/7/1

N2 - Cardiovascular disease (CVD) is higher in people with mental illness and is associated with a 30 year higher mortality rate in this population. Erythrocyte docosahexaenoic acid (DHA) plus eicosapentaenoic acid (EPA) (omega-3 index)≤4% is a marker for increased mortality risk from CVD while >8% is protective. Omega-3 polyunsaturated fatty acids are also important for brain function and may ameliorate symptoms of mental illness. We investigated the erythrocyte omega-3 index in people with mental illness. One hundred and thirty adults aged 18-65 years (32.6% male) with schizophrenia (n=14) and depression (n=116) provided blood samples and completed physiological assessments and questionnaires. Both populations had risk factors for metabolic syndrome and CVD. The average omega-3 index was 3.95% (SD=1.06), compared to an estimated 5% in the Australian population. These data indicate an unfavourable omega-3 profile in people with mental illness that could contribute to higher CVD risk.

AB - Cardiovascular disease (CVD) is higher in people with mental illness and is associated with a 30 year higher mortality rate in this population. Erythrocyte docosahexaenoic acid (DHA) plus eicosapentaenoic acid (EPA) (omega-3 index)≤4% is a marker for increased mortality risk from CVD while >8% is protective. Omega-3 polyunsaturated fatty acids are also important for brain function and may ameliorate symptoms of mental illness. We investigated the erythrocyte omega-3 index in people with mental illness. One hundred and thirty adults aged 18-65 years (32.6% male) with schizophrenia (n=14) and depression (n=116) provided blood samples and completed physiological assessments and questionnaires. Both populations had risk factors for metabolic syndrome and CVD. The average omega-3 index was 3.95% (SD=1.06), compared to an estimated 5% in the Australian population. These data indicate an unfavourable omega-3 profile in people with mental illness that could contribute to higher CVD risk.

KW - Cardiovascular disease

KW - Depression

KW - Mental illness

KW - Omega-3

KW - Omega-3 index

KW - Polyunsaturated fatty acids

KW - Schizophrenia

UR - http://www.scopus.com/inward/record.url?scp=84969972553&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84969972553&partnerID=8YFLogxK

U2 - 10.1016/j.plefa.2016.05.007

DO - 10.1016/j.plefa.2016.05.007

M3 - Article

C2 - 27255642

AN - SCOPUS:84969972553

SN - 0952-3278

VL - 110

SP - 42

EP - 47

JO - Prostaglandins Leukotrienes and Essential Fatty Acids

JF - Prostaglandins Leukotrienes and Essential Fatty Acids

ER -

People with schizophrenia and depression have a low omega-3 index

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this