Pentostatin - Pharmacology, immunology, and clinical effects in graft-versus-host disease

Meghan Higman, Georgia B. Vogelsang, Allen Chen

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations


Pentostatin (deoxycoformycin), is one of a number of purine analogues. The drug was originally designed to mimic a form of severe combined immune deficiency, characterised by marked T lymphopenia but variable B cell function. Clinically, the drug has been used primarily to treat a rare type of leukaemia - hairy cell leukaemia. Recently, the drug has seen increasing attention as an immunosuppressant. This review will cover the basic pharmacology and immunological effects of pentostatin. The clinical use of this agent in prevention and treatment of graft-versus-host disease will be examined. Although many of these studies are ongoing, this agent has promise as a novel immunosuppressive agent with a new mechanism of action.

Original languageEnglish (US)
Pages (from-to)2605-2613
Number of pages9
JournalExpert opinion on pharmacotherapy
Issue number12
StatePublished - Dec 2004


  • Bone marrow transplantation
  • Graft versus host disease
  • Immunosuppression
  • Purine analogues

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)


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