TY - JOUR
T1 - Pentostatin - Pharmacology, immunology, and clinical effects in graft-versus-host disease
AU - Higman, Meghan
AU - Vogelsang, Georgia B.
AU - Chen, Allen
N1 - Funding Information:
Several other trials of pentostatin for treatment of steroid refractory chronic GVHD are currently ongoing. Pentostatin is one of the agents being examined in a randomised Phase II study of initial therapy for GVHD by the NIH sponsored Clinical Trials Network.
PY - 2004/12
Y1 - 2004/12
N2 - Pentostatin (deoxycoformycin), is one of a number of purine analogues. The drug was originally designed to mimic a form of severe combined immune deficiency, characterised by marked T lymphopenia but variable B cell function. Clinically, the drug has been used primarily to treat a rare type of leukaemia - hairy cell leukaemia. Recently, the drug has seen increasing attention as an immunosuppressant. This review will cover the basic pharmacology and immunological effects of pentostatin. The clinical use of this agent in prevention and treatment of graft-versus-host disease will be examined. Although many of these studies are ongoing, this agent has promise as a novel immunosuppressive agent with a new mechanism of action.
AB - Pentostatin (deoxycoformycin), is one of a number of purine analogues. The drug was originally designed to mimic a form of severe combined immune deficiency, characterised by marked T lymphopenia but variable B cell function. Clinically, the drug has been used primarily to treat a rare type of leukaemia - hairy cell leukaemia. Recently, the drug has seen increasing attention as an immunosuppressant. This review will cover the basic pharmacology and immunological effects of pentostatin. The clinical use of this agent in prevention and treatment of graft-versus-host disease will be examined. Although many of these studies are ongoing, this agent has promise as a novel immunosuppressive agent with a new mechanism of action.
KW - Bone marrow transplantation
KW - Graft versus host disease
KW - Immunosuppression
KW - Purine analogues
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U2 - 10.1517/14656566.5.12.2605
DO - 10.1517/14656566.5.12.2605
M3 - Review article
C2 - 15571477
AN - SCOPUS:10644233140
SN - 1465-6566
VL - 5
SP - 2605
EP - 2613
JO - Expert opinion on pharmacotherapy
JF - Expert opinion on pharmacotherapy
IS - 12
ER -