TY - JOUR
T1 - Penicillium marneffei Infection in Patients Infected with Human Immunodeficiency Virus
AU - Supparatpinyo, Khuanchai
AU - Chiewchanvit, Siri
AU - Hirunsri, Panit
AU - Uthammachai, Chantana
AU - Nelson, Kenrad E.
AU - Sirisanthana, Thira
PY - 1992/4/1
Y1 - 1992/4/1
N2 - From June 1990 to August 1991, 21 patients infected with the human immunodeficiency virus (HIV) presented with systemic mycosis caused by Penicillium marneffei. Between August 1987 and August 1991, only five patients were observed who had P. marneffei infection but not HIV infection. The clinical presentation included fever, cough, and generalized papular skin lesions. For 11 of these 21 patients, the presumptive diagnosis of P. marneffei infection could be made by microscopic examination of Wright’s-stained bone marrow aspirate and/or touch smears of skin specimens obtained by biopsy several days before the results of culture were available. Initial clinical response to treatment with either parenteral amphotericin B or oral itraconazole was favorable in most patients. Epidemiological and clinical evidence suggest that this systemic mycosis is caused by an important opportunistic pathogen and that it should be included in the differential diagnosis of AIDS, at least for countries in areas of endemicity, i.e., Southeast Asia and China.
AB - From June 1990 to August 1991, 21 patients infected with the human immunodeficiency virus (HIV) presented with systemic mycosis caused by Penicillium marneffei. Between August 1987 and August 1991, only five patients were observed who had P. marneffei infection but not HIV infection. The clinical presentation included fever, cough, and generalized papular skin lesions. For 11 of these 21 patients, the presumptive diagnosis of P. marneffei infection could be made by microscopic examination of Wright’s-stained bone marrow aspirate and/or touch smears of skin specimens obtained by biopsy several days before the results of culture were available. Initial clinical response to treatment with either parenteral amphotericin B or oral itraconazole was favorable in most patients. Epidemiological and clinical evidence suggest that this systemic mycosis is caused by an important opportunistic pathogen and that it should be included in the differential diagnosis of AIDS, at least for countries in areas of endemicity, i.e., Southeast Asia and China.
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U2 - 10.1093/clinids/14.4.871
DO - 10.1093/clinids/14.4.871
M3 - Article
C2 - 1315586
AN - SCOPUS:0026534238
SN - 1058-4838
VL - 14
SP - 871
EP - 874
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
IS - 4
ER -