Pediatric Soft Tissue Sarcomas

David M. Loeb, Katherine Thornton, Ori Shokek

Research output: Contribution to journalReview articlepeer-review

65 Scopus citations


Soft tissue sarcomas in children are rare. Approximately 850 to 900 children and adolescents are diagnosed each year with rhabdomyosarcoma (RMS) or a non-RMS soft tissue sarcoma (NRSTS). RMS is more common in children 14 years old and younger and NRSTS in adolescents and young adults. Infants get NRSTS, but their tumors constitute a distinctive set of histologies. Surgery is a major therapeutic modality and radiation plays a role. RMS is treated with adjuvant chemotherapy, whereas chemotherapy is reserved for the NRSTS that are high grade or unresectable. This review discusses the etiology, biology, and treatment of pediatric soft tissue sarcomas.

Original languageEnglish (US)
Pages (from-to)615-627
Number of pages13
JournalSurgical Clinics of North America
Issue number3
StatePublished - Jun 2008
Externally publishedYes

ASJC Scopus subject areas

  • Surgery


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