Pediatric renal cell carcinoma

Justin E. Sausville, David J. Hernandez, Pedram Argani, John P. Gearhart

Research output: Contribution to journalArticlepeer-review

42 Scopus citations


Renal cell carcinoma (RCC) comprises about 5% of pediatric renal neoplasms. It has been recognized as a second malignancy in multiple reports. It is generally symptomatic at diagnosis, and most children with RCC present with more locally advanced disease than do adults. Contemporary investigation of pediatric RCC has demonstrated that a large percentage of these tumors bear cytogenetic translocations involving the MiT family of transcription factors. Surgical therapy for these children resembles operative intervention for adult RCC, though debate continues about the precise role of lymph node dissection. There are no adequately powered studies to support conclusions about adjuvant or neoadjuvant chemotherapy for children with RCC. This may be ameliorated by a multi-institutional protocol which is enrolling patients.

Original languageEnglish (US)
Pages (from-to)308-314
Number of pages7
JournalJournal of pediatric urology
Issue number4
StatePublished - Aug 1 2009


  • MiT
  • Pediatric renal cell carcinoma
  • Second malignancy
  • TFE3
  • Translocation RCC

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Urology


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