Pediatric psychopharmacology and the interaction between drugs and the developing brain

Benedetto Vitiello

Research output: Contribution to journalReview articlepeer-review

56 Scopus citations


With increasing frequency, psychotropic medications are being prescribed to young children, often for long periods of time. The interaction between psychotropics and the developing brain has not been systematically investigated in humans. Data collected from animals suggest that developing neurotransmitter systems can be exquisitely sensitive to early inhibition or stimulation by pharmacological agents, which can lead to permanent changes in adult life. Most of these data are collected from rodents, and their extrapolation to humans is difficult. More relevant models could be developed, for instance using primates. In humans, the focus of research has traditionally been on the possible teratogenic effects of prenatal drug exposure. Recently introduced quantitative imaging techniques can offer new approaches to studying the effects of psychotropics on the developing brain. This research has clear implications for the safety and efficacy of psychopharmacologic drug use in children.

Original languageEnglish (US)
Pages (from-to)582-584
Number of pages3
JournalCanadian Journal of Psychiatry
Issue number6
StatePublished - Jan 1 1998


  • Brain
  • Development
  • Psychopharmacology

ASJC Scopus subject areas

  • Psychiatry and Mental health


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