Pediatric patients with chronic kidney disease-mineral bone disorder

Juhi Kumar, Susan L. Furth, Bradley A. Warady

Research output: Contribution to journalArticlepeer-review


Chronic kidney disease-mineral bone disorder (CKD-MBD) is a systemic disorder of mineral and bone metabolism that has deleterious consequences on skeletal and cardiovascular health. Nowhere is the morbidity of this disorder more telling than in children. During childhood and adolescence, CKD-MBD may result in poor growth and skeletal deformities, while the mineral dysregulation can manifest in cardiovascular disease in early adulthood, a development that places the patients at high risk for severe morbidity and early mortality. Unfortunately, management of CKD-MBD has been less than satisfactory in children despite recent advances and is limited by the lack of evidence-based treatment guidelines. More positive are ongoing research efforts, such as the Chronic Kidney Disease in Children and the Cardiovascular Comorbidity in Children with CKD (4C) studies that are currently providing important insights which should help better elucidate the pathogenesis and progression of mineral dysregulation and its clinical impact in children. Data from these studies and others will undoubtedly also help formulate clinical trials and the generation of evidence-based therapeutic options designed to provide more effective management of CKD-MBD in the pediatric population.

Original languageEnglish (US)
Pages (from-to)219-234
Number of pages16
JournalClinical Reviews in Bone and Mineral Metabolism
Issue number3
StatePublished - Sep 1 2012


  • Chronic kidney disease
  • FGF 23
  • Mineral dysregulation
  • Pediatric
  • Renal osteodystrophy
  • Secondary hyperparathyroidism
  • Vascular calcification
  • Vitamin D

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine
  • Endocrinology


Dive into the research topics of 'Pediatric patients with chronic kidney disease-mineral bone disorder'. Together they form a unique fingerprint.

Cite this