Pediatric intestinal transplantation

Eliza J. Lee; George V. Mazariegos; Geoffrey J. Bond

doi:10.1016/j.sempedsurg.2022.151181

Pediatric intestinal transplantation

Eliza J. Lee, George V. Mazariegos, Geoffrey J. Bond

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Advancements in donor management, organ preservation and operative techniques, as well as immunosuppressive therapies, have provided children with intestinal failure and its complications a chance not only for enteral autonomy but also long-term survival through intestinal transplantation (ITx). First described in the 1960’s, experience has grown in managing these complex patients both pre- and post-transplant. The goals of this review are to provide a brief history of intestinal transplantation and intestinal rehabilitation in pediatric patients, followed by focused discussions of the indications for ITx, induction and maintenance immunosuppression therapies, common post-operative complications, and outcomes/quality of life post-transplant.

Original language	English (US)
Article number	151181
Journal	Seminars in pediatric surgery
Volume	31
Issue number	3
DOIs	https://doi.org/10.1016/j.sempedsurg.2022.151181
State	Published - Jun 2022

Keywords

Immunosuppression
Infection
Intestinal failure
Intestinal transplant
Post-transplant lymphoproliferative disease
Post-transplant outcomes

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Surgery

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10.1016/j.sempedsurg.2022.151181

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title = "Pediatric intestinal transplantation",

abstract = "Advancements in donor management, organ preservation and operative techniques, as well as immunosuppressive therapies, have provided children with intestinal failure and its complications a chance not only for enteral autonomy but also long-term survival through intestinal transplantation (ITx). First described in the 1960{\textquoteright}s, experience has grown in managing these complex patients both pre- and post-transplant. The goals of this review are to provide a brief history of intestinal transplantation and intestinal rehabilitation in pediatric patients, followed by focused discussions of the indications for ITx, induction and maintenance immunosuppression therapies, common post-operative complications, and outcomes/quality of life post-transplant.",

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AU - Mazariegos, George V.

AU - Bond, Geoffrey J.

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AB - Advancements in donor management, organ preservation and operative techniques, as well as immunosuppressive therapies, have provided children with intestinal failure and its complications a chance not only for enteral autonomy but also long-term survival through intestinal transplantation (ITx). First described in the 1960’s, experience has grown in managing these complex patients both pre- and post-transplant. The goals of this review are to provide a brief history of intestinal transplantation and intestinal rehabilitation in pediatric patients, followed by focused discussions of the indications for ITx, induction and maintenance immunosuppression therapies, common post-operative complications, and outcomes/quality of life post-transplant.

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KW - Infection

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KW - Post-transplant lymphoproliferative disease

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Pediatric intestinal transplantation

Abstract

Keywords

ASJC Scopus subject areas

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