Pediatric HCT in Florida (2014 -2016): A report from the FPBCC

Deepak Chellapandian; Gauri Sunkersett; Benjamin Oshrine; Jorge Galvez Silva; Edward Ziga; Warren Alperstein; Michael Joyce; Howard Katzenstein; Kamar Godder; Paul Castillo; Julio Barredo; John Fort; Peter H. Shaw; Michael L. Nieder; Jessica Cline; Fan Yang; Biljana Horn

doi:10.1111/petr.13931

Pediatric HCT in Florida (2014 -2016): A report from the FPBCC

Deepak Chellapandian, Gauri Sunkersett, Benjamin Oshrine, Jorge Galvez Silva, Edward Ziga, Warren Alperstein, Michael Joyce, Howard Katzenstein, Kamar Godder, Paul Castillo, Julio Barredo, John Fort, Peter H. Shaw, Michael L. Nieder, Jessica Cline, Fan Yang, Biljana Horn

All Children's Hospital

Research output: Contribution to journal › Article › peer-review

Abstract

FPBCC was formed in 2018 by five pediatric transplant programs in Florida. One of the key objectives of the consortium is to provide outcome analyses by combining HCT data from all the participating centers in order to identify areas for improvement. In this first FPBCC landscape report we describe the patient and transplant characteristics of pediatric patients undergoing first allo and auto HCT between 2014 and 2016 in Florida. The source of data was eDBtC of the CIBMTR. Over the span of 3 years, a total of 230 pediatric patients underwent allo-HCT and 104 underwent auto-HCT at the participating centers. The most significant predictor of survival in allo-HCT recipients with malignant disorders was the degree of HLA- match, while in the recipients of allo-HCT with non-malignant disorders the predictors of survival included age, donor relationship and degree of HLA match. Our analyses identified the need to improve reporting of primary cause of death and improve on donor selection process given that the degree of HLA match remains the most important predictor of survival. This first FPBCC-wide review describes the trends in pediatric HCT activity between 2014 and 2016 among the participating centers in Florida and confirms feasibility of using eDBtC data platform and collaborative approach in order to identify areas for improvement in outcomes.

Original language	English (US)
Article number	e13931
Journal	Pediatric transplantation
Volume	25
Issue number	5
DOIs	https://doi.org/10.1111/petr.13931
State	Published - Aug 2021

Keywords

Florida consortium
outcomes
pediatric HCT

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Transplantation

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10.1111/petr.13931

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Chellapandian, D., Sunkersett, G., Oshrine, B., Galvez Silva, J., Ziga, E., Alperstein, W., Joyce, M., Katzenstein, H., Godder, K., Castillo, P., Barredo, J., Fort, J., Shaw, P. H., Nieder, M. L., Cline, J., Yang, F., & Horn, B. (2021). Pediatric HCT in Florida (2014 -2016): A report from the FPBCC. Pediatric transplantation, 25(5), Article e13931. https://doi.org/10.1111/petr.13931

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title = "Pediatric HCT in Florida (2014 -2016): A report from the FPBCC",

abstract = "FPBCC was formed in 2018 by five pediatric transplant programs in Florida. One of the key objectives of the consortium is to provide outcome analyses by combining HCT data from all the participating centers in order to identify areas for improvement. In this first FPBCC landscape report we describe the patient and transplant characteristics of pediatric patients undergoing first allo and auto HCT between 2014 and 2016 in Florida. The source of data was eDBtC of the CIBMTR. Over the span of 3 years, a total of 230 pediatric patients underwent allo-HCT and 104 underwent auto-HCT at the participating centers. The most significant predictor of survival in allo-HCT recipients with malignant disorders was the degree of HLA- match, while in the recipients of allo-HCT with non-malignant disorders the predictors of survival included age, donor relationship and degree of HLA match. Our analyses identified the need to improve reporting of primary cause of death and improve on donor selection process given that the degree of HLA match remains the most important predictor of survival. This first FPBCC-wide review describes the trends in pediatric HCT activity between 2014 and 2016 among the participating centers in Florida and confirms feasibility of using eDBtC data platform and collaborative approach in order to identify areas for improvement in outcomes.",

keywords = "Florida consortium, outcomes, pediatric HCT",

author = "Deepak Chellapandian and Gauri Sunkersett and Benjamin Oshrine and {Galvez Silva}, Jorge and Edward Ziga and Warren Alperstein and Michael Joyce and Howard Katzenstein and Kamar Godder and Paul Castillo and Julio Barredo and John Fort and Shaw, {Peter H.} and Nieder, {Michael L.} and Jessica Cline and Fan Yang and Biljana Horn",

note = "Funding Information: We acknowledge the support from Dr Douglas Rizzo, Senior Scientific Director from CIBMTR who introduced us to the eDBtC platform. We also acknowledge the Children's Miracle Network grant for foundation of FPBCC. The CIBMTR is supported primarily by Public Health Service grant/cooperative agreement U24CA076518 with the National Cancer Institute (NCI), the National Heart, Lung and Blood Institute (NHLBI) and the National Institute of Allergy and Infectious Diseases (NIAID); grant/cooperative agreement U24HL138660 with NHLBI and NCI; grant U24CA233032 from the NCI; grants OT3HL147741, R21HL140314 and U01HL128568 from the NHLBI; contract HHSH250201700006C with Health Resources and Services Administration (HRSA); grants N00014‐18‐1‐2888 and N00014‐17‐1‐2850 from the Office of Naval Research; subaward from prime contract award SC1MC31881‐01‐00 with HRSA; subawards from prime grant awards R01HL131731 and R01HL126589 from NHLBI; subawards from prime grant awards 5P01CA111412, 5R01HL129472, R01CA152108, 1R01HL131731, 1U01AI126612 and 1R01CA231141 from the NIH. Publisher Copyright: {\textcopyright} 2020 Wiley Periodicals LLC",

year = "2021",

month = aug,

doi = "10.1111/petr.13931",

language = "English (US)",

volume = "25",

journal = "Pediatric transplantation",

issn = "1397-3142",

publisher = "Wiley-Blackwell",

number = "5",

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T1 - Pediatric HCT in Florida (2014 -2016)

T2 - A report from the FPBCC

AU - Chellapandian, Deepak

AU - Sunkersett, Gauri

AU - Oshrine, Benjamin

AU - Galvez Silva, Jorge

AU - Ziga, Edward

AU - Alperstein, Warren

AU - Joyce, Michael

AU - Katzenstein, Howard

AU - Godder, Kamar

AU - Castillo, Paul

AU - Barredo, Julio

AU - Fort, John

AU - Shaw, Peter H.

AU - Nieder, Michael L.

AU - Cline, Jessica

AU - Yang, Fan

AU - Horn, Biljana

N1 - Funding Information: We acknowledge the support from Dr Douglas Rizzo, Senior Scientific Director from CIBMTR who introduced us to the eDBtC platform. We also acknowledge the Children's Miracle Network grant for foundation of FPBCC. The CIBMTR is supported primarily by Public Health Service grant/cooperative agreement U24CA076518 with the National Cancer Institute (NCI), the National Heart, Lung and Blood Institute (NHLBI) and the National Institute of Allergy and Infectious Diseases (NIAID); grant/cooperative agreement U24HL138660 with NHLBI and NCI; grant U24CA233032 from the NCI; grants OT3HL147741, R21HL140314 and U01HL128568 from the NHLBI; contract HHSH250201700006C with Health Resources and Services Administration (HRSA); grants N00014‐18‐1‐2888 and N00014‐17‐1‐2850 from the Office of Naval Research; subaward from prime contract award SC1MC31881‐01‐00 with HRSA; subawards from prime grant awards R01HL131731 and R01HL126589 from NHLBI; subawards from prime grant awards 5P01CA111412, 5R01HL129472, R01CA152108, 1R01HL131731, 1U01AI126612 and 1R01CA231141 from the NIH. Publisher Copyright: © 2020 Wiley Periodicals LLC

PY - 2021/8

Y1 - 2021/8

N2 - FPBCC was formed in 2018 by five pediatric transplant programs in Florida. One of the key objectives of the consortium is to provide outcome analyses by combining HCT data from all the participating centers in order to identify areas for improvement. In this first FPBCC landscape report we describe the patient and transplant characteristics of pediatric patients undergoing first allo and auto HCT between 2014 and 2016 in Florida. The source of data was eDBtC of the CIBMTR. Over the span of 3 years, a total of 230 pediatric patients underwent allo-HCT and 104 underwent auto-HCT at the participating centers. The most significant predictor of survival in allo-HCT recipients with malignant disorders was the degree of HLA- match, while in the recipients of allo-HCT with non-malignant disorders the predictors of survival included age, donor relationship and degree of HLA match. Our analyses identified the need to improve reporting of primary cause of death and improve on donor selection process given that the degree of HLA match remains the most important predictor of survival. This first FPBCC-wide review describes the trends in pediatric HCT activity between 2014 and 2016 among the participating centers in Florida and confirms feasibility of using eDBtC data platform and collaborative approach in order to identify areas for improvement in outcomes.

AB - FPBCC was formed in 2018 by five pediatric transplant programs in Florida. One of the key objectives of the consortium is to provide outcome analyses by combining HCT data from all the participating centers in order to identify areas for improvement. In this first FPBCC landscape report we describe the patient and transplant characteristics of pediatric patients undergoing first allo and auto HCT between 2014 and 2016 in Florida. The source of data was eDBtC of the CIBMTR. Over the span of 3 years, a total of 230 pediatric patients underwent allo-HCT and 104 underwent auto-HCT at the participating centers. The most significant predictor of survival in allo-HCT recipients with malignant disorders was the degree of HLA- match, while in the recipients of allo-HCT with non-malignant disorders the predictors of survival included age, donor relationship and degree of HLA match. Our analyses identified the need to improve reporting of primary cause of death and improve on donor selection process given that the degree of HLA match remains the most important predictor of survival. This first FPBCC-wide review describes the trends in pediatric HCT activity between 2014 and 2016 among the participating centers in Florida and confirms feasibility of using eDBtC data platform and collaborative approach in order to identify areas for improvement in outcomes.

KW - Florida consortium

KW - outcomes

KW - pediatric HCT

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UR - http://www.scopus.com/inward/citedby.url?scp=85096647244&partnerID=8YFLogxK

U2 - 10.1111/petr.13931

DO - 10.1111/petr.13931

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AN - SCOPUS:85096647244

SN - 1397-3142

VL - 25

JO - Pediatric transplantation

JF - Pediatric transplantation

IS - 5

M1 - e13931

ER -

Pediatric HCT in Florida (2014 -2016): A report from the FPBCC

Abstract

Keywords

ASJC Scopus subject areas

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