Pediatric decision-making: Informed consent, parental permission, and child assent

Yoram Unguru

Research output: Chapter in Book/Report/Conference proceedingChapter

7 Scopus citations


Case narrative Osteosarcoma is a highly malignant bone cancer with a predilection for spreading to the lungs that primarily affects adolescents. Non-metastatic osteosarcoma has an approximate cure rate of 70%. Patients with osteosarcoma and metastases at the time of diagnosis are cured less than 20% of the time. Treatment consists of surgery and chemotherapy. Many children with cancer are treated according to clinical research trials. Michael, a 15-year-old with metastatic osteosarcoma, has not responded to conventional therapy. For almost one year, he was treated on a therapeutic randomized clinical trial, which consisted of standard therapy (up-front chemotherapy, limb salvage surgery, and postsurgical chemotherapy). When his cancer responded poorly to up-front therapy he was randomized to receive additional “experimental” chemotherapy.

Original languageEnglish (US)
Title of host publicationClinical Ethics in Pediatrics
Subtitle of host publicationA Case-Based Textbook
PublisherCambridge University Press
Number of pages6
ISBN (Electronic)9780511740336
ISBN (Print)9780521173612
StatePublished - Jan 1 2011
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


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