Pediatric corneal transplants

Danielle Trief, Maria C. Marquezan, Christopher J. Rapuano, Christina Rapp Prescott

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations


Purpose of reviewPediatric keratoplasty poses unique challenges in clinical and surgical management. However, successful transplantation can afford a child vision in an otherwise poorly seeing eye. This review will provide an update on recent advances in pediatric keratoplasty.Recent findingsAlthough children who receive corneal transplants remain at increased risk of rejection, infection, and graft dehiscence compared with adult corneal transplant recipients, new surgical techniques, and advances in clinical management have led to better outcomes. Surgical modifications in penetrating keratoplasty (PKP) offer increased stabilization of the delicate pediatric eye. Lamellar surgery, including endothelial keratoplasty and deep anterior lamellar keratoplasty, can target specific diseased tissue in children with potentially fewer complications. The keratoprosthesis can be used successfully in children when the chance of success with PKP is especially low.SummaryAs our knowledge of prognostic indicators and surgical techniques continues to grow, we can offer children safer and more targeted surgeries for some of the most challenging corneal diseases. Ultimately, successful transplantation with long-term graft survival can be obtained by a multidisciplinary approach, with care across ophthalmic specialties, and a commitment to long-term follow-up by the patient's family.

Original languageEnglish (US)
Pages (from-to)477-484
Number of pages8
JournalCurrent Opinion in Ophthalmology
Issue number5
StatePublished - Sep 1 2017


  • deep anterior lamellar keratoplasty
  • Descemet's stripping automated endothelial keratoplasty
  • Descemet's stripping endothelial keratoplasty
  • keratoprosthesis
  • pediatric keratoplasty
  • PKP

ASJC Scopus subject areas

  • Ophthalmology


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