TY - JOUR
T1 - PDMS-PEG Block Copolymer and Pretreatment for Arresting Drug Absorption in Microphysiological Devices
AU - Mair, Devin B.
AU - Williams, Marcus Alonso Cee
AU - Chen, Jeffrey Fanzhi
AU - Goldstein, Alex
AU - Wu, Alex
AU - Lee, Peter H.U.
AU - Sniadecki, Nathan J.
AU - Kim, Deok Ho
N1 - Publisher Copyright:
© 2022 American Chemical Society.
PY - 2022/8/31
Y1 - 2022/8/31
N2 - Poly(dimethylsiloxane) (PDMS) is a commonly used polymer in organ-on-a-chip devices and microphysiological systems. However, due to its hydrophobicity and permeability, it absorbs drug compounds, preventing accurate drug screening applications. Here, we developed an effective and facile method to prevent the absorption of drugs by utilizing a PDMS-PEG block copolymer additive and drug pretreatment. First, we incorporated a PDMS-PEG block copolymer into PDMS to address its inherent hydrophobicity. Next, we addressed the permeability of PDMS by eliminating the concentration gradient via pretreatment of the PDMS with the drug prior to experimentally testing drug absorption. The combined use of a PDMS-PEG block copolymer with drug pretreatment resulted in a mean reduction of drug absorption by 91.6% in the optimal condition. Finally, we demonstrated that the proposed method can be applied to prevent drug absorption in a PDMS-based cardiac microphysiological system, enabling more accurate drug studies.
AB - Poly(dimethylsiloxane) (PDMS) is a commonly used polymer in organ-on-a-chip devices and microphysiological systems. However, due to its hydrophobicity and permeability, it absorbs drug compounds, preventing accurate drug screening applications. Here, we developed an effective and facile method to prevent the absorption of drugs by utilizing a PDMS-PEG block copolymer additive and drug pretreatment. First, we incorporated a PDMS-PEG block copolymer into PDMS to address its inherent hydrophobicity. Next, we addressed the permeability of PDMS by eliminating the concentration gradient via pretreatment of the PDMS with the drug prior to experimentally testing drug absorption. The combined use of a PDMS-PEG block copolymer with drug pretreatment resulted in a mean reduction of drug absorption by 91.6% in the optimal condition. Finally, we demonstrated that the proposed method can be applied to prevent drug absorption in a PDMS-based cardiac microphysiological system, enabling more accurate drug studies.
KW - PDMS
KW - PDMS-PEG
KW - drug absorption
KW - microphysiological systems
KW - organ-on-a-chip
UR - http://www.scopus.com/inward/record.url?scp=85137136159&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85137136159&partnerID=8YFLogxK
U2 - 10.1021/acsami.2c10669
DO - 10.1021/acsami.2c10669
M3 - Article
C2 - 35984038
AN - SCOPUS:85137136159
SN - 1944-8244
JO - ACS Applied Materials and Interfaces
JF - ACS Applied Materials and Interfaces
ER -