PDMS-PEG Block Copolymer and Pretreatment for Arresting Drug Absorption in Microphysiological Devices

Devin B. Mair, Marcus Alonso Cee Williams, Jeffrey Fanzhi Chen, Alex Goldstein, Alex Wu, Peter H.U. Lee, Nathan J. Sniadecki, Deok Ho Kim

Research output: Contribution to journalArticlepeer-review

Abstract

Poly(dimethylsiloxane) (PDMS) is a commonly used polymer in organ-on-a-chip devices and microphysiological systems. However, due to its hydrophobicity and permeability, it absorbs drug compounds, preventing accurate drug screening applications. Here, we developed an effective and facile method to prevent the absorption of drugs by utilizing a PDMS-PEG block copolymer additive and drug pretreatment. First, we incorporated a PDMS-PEG block copolymer into PDMS to address its inherent hydrophobicity. Next, we addressed the permeability of PDMS by eliminating the concentration gradient via pretreatment of the PDMS with the drug prior to experimentally testing drug absorption. The combined use of a PDMS-PEG block copolymer with drug pretreatment resulted in a mean reduction of drug absorption by 91.6% in the optimal condition. Finally, we demonstrated that the proposed method can be applied to prevent drug absorption in a PDMS-based cardiac microphysiological system, enabling more accurate drug studies.

Original languageEnglish (US)
JournalACS Applied Materials and Interfaces
DOIs
StatePublished - Aug 31 2022

Keywords

  • PDMS
  • PDMS-PEG
  • drug absorption
  • microphysiological systems
  • organ-on-a-chip

ASJC Scopus subject areas

  • General Materials Science

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