PDGF induces osteoprotegerin expression in vascular smooth muscle cells by multiple signal pathways

Jifeng Zhang; Mingui Fu; David Myles; Xiaojun Zhu; Jie Du; Xu Cao; Yuqing E. Chen

doi:10.1016/S0014-5793(02)02872-7

PDGF induces osteoprotegerin expression in vascular smooth muscle cells by multiple signal pathways

Jifeng Zhang, Mingui Fu, David Myles, Xiaojun Zhu, Jie Du, Xu Cao, Yuqing E. Chen

Research output: Contribution to journal › Article › peer-review

141 Scopus citations

Abstract

Osteoprotegerin (OPG) is a key regulator of osteoclastogenesis. Recent reports suggest that OPG may function as a protector of arterial calcification and survival of endothelial cells. However, the role and expression of OPG in vascular wall is unclear. Here we report that OPG was highly expressed in vascular smooth muscle cells (VSMC) but not in endothelial cells. Platelet-derived growth factor (PDGF), basic fibroblast growth factor, angiotensin II, tumor necrosis factor α and interleukin-1β upregulated OPG expression in VSMC. Moreover, inhibition of phosphatidylinositol 3-kinase/Akt or P38-signal pathway abrogated PDGF-induced OPG expression. Our results suggest that OPG may be an important determinant of vascular homeostasis.

Original language	English (US)
Pages (from-to)	180-184
Number of pages	5
Journal	FEBS Letters
Volume	521
Issue number	1-3
DOIs	https://doi.org/10.1016/S0014-5793(02)02872-7
State	Published - Jun 19 2002
Externally published	Yes

Keywords

Gene expression
Osteoprotegerin
Platelet-derived growth factor
Signaling pathway
Vascular smooth muscle cell

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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10.1016/S0014-5793(02)02872-7

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title = "PDGF induces osteoprotegerin expression in vascular smooth muscle cells by multiple signal pathways",

abstract = "Osteoprotegerin (OPG) is a key regulator of osteoclastogenesis. Recent reports suggest that OPG may function as a protector of arterial calcification and survival of endothelial cells. However, the role and expression of OPG in vascular wall is unclear. Here we report that OPG was highly expressed in vascular smooth muscle cells (VSMC) but not in endothelial cells. Platelet-derived growth factor (PDGF), basic fibroblast growth factor, angiotensin II, tumor necrosis factor α and interleukin-1β upregulated OPG expression in VSMC. Moreover, inhibition of phosphatidylinositol 3-kinase/Akt or P38-signal pathway abrogated PDGF-induced OPG expression. Our results suggest that OPG may be an important determinant of vascular homeostasis.",

keywords = "Gene expression, Osteoprotegerin, Platelet-derived growth factor, Signaling pathway, Vascular smooth muscle cell",

author = "Jifeng Zhang and Mingui Fu and David Myles and Xiaojun Zhu and Jie Du and Xu Cao and Chen, {Yuqing E.}",

note = "Funding Information: This work was partially supported by a starting grant from Morehouse Cardiovascular Research Institute (Enhancement of Cardiovascular and Related Research Areas, NIH/NHLBI 5 UH1 HL03676-02), an institutional grant (NIH/NIHGMS S06GM08248), an NIH grant R01HL068878 (Y.E.C.), the American Heart Association (Y.E.C.), as well as China State Major Basic Research development Program (No. G2000056905).",

year = "2002",

month = jun,

day = "19",

doi = "10.1016/S0014-5793(02)02872-7",

language = "English (US)",

volume = "521",

pages = "180--184",

journal = "FEBS Letters",

issn = "0014-5793",

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number = "1-3",

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TY - JOUR

T1 - PDGF induces osteoprotegerin expression in vascular smooth muscle cells by multiple signal pathways

AU - Zhang, Jifeng

AU - Fu, Mingui

AU - Myles, David

AU - Zhu, Xiaojun

AU - Du, Jie

AU - Cao, Xu

AU - Chen, Yuqing E.

N1 - Funding Information: This work was partially supported by a starting grant from Morehouse Cardiovascular Research Institute (Enhancement of Cardiovascular and Related Research Areas, NIH/NHLBI 5 UH1 HL03676-02), an institutional grant (NIH/NIHGMS S06GM08248), an NIH grant R01HL068878 (Y.E.C.), the American Heart Association (Y.E.C.), as well as China State Major Basic Research development Program (No. G2000056905).

PY - 2002/6/19

Y1 - 2002/6/19

N2 - Osteoprotegerin (OPG) is a key regulator of osteoclastogenesis. Recent reports suggest that OPG may function as a protector of arterial calcification and survival of endothelial cells. However, the role and expression of OPG in vascular wall is unclear. Here we report that OPG was highly expressed in vascular smooth muscle cells (VSMC) but not in endothelial cells. Platelet-derived growth factor (PDGF), basic fibroblast growth factor, angiotensin II, tumor necrosis factor α and interleukin-1β upregulated OPG expression in VSMC. Moreover, inhibition of phosphatidylinositol 3-kinase/Akt or P38-signal pathway abrogated PDGF-induced OPG expression. Our results suggest that OPG may be an important determinant of vascular homeostasis.

AB - Osteoprotegerin (OPG) is a key regulator of osteoclastogenesis. Recent reports suggest that OPG may function as a protector of arterial calcification and survival of endothelial cells. However, the role and expression of OPG in vascular wall is unclear. Here we report that OPG was highly expressed in vascular smooth muscle cells (VSMC) but not in endothelial cells. Platelet-derived growth factor (PDGF), basic fibroblast growth factor, angiotensin II, tumor necrosis factor α and interleukin-1β upregulated OPG expression in VSMC. Moreover, inhibition of phosphatidylinositol 3-kinase/Akt or P38-signal pathway abrogated PDGF-induced OPG expression. Our results suggest that OPG may be an important determinant of vascular homeostasis.

KW - Gene expression

KW - Osteoprotegerin

KW - Platelet-derived growth factor

KW - Signaling pathway

KW - Vascular smooth muscle cell

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DO - 10.1016/S0014-5793(02)02872-7

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JO - FEBS Letters

JF - FEBS Letters

IS - 1-3

ER -

PDGF induces osteoprotegerin expression in vascular smooth muscle cells by multiple signal pathways

Abstract

Keywords

ASJC Scopus subject areas

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