@article{bced358387624c6683628d02a85b7616,
title = "Patient-Specific Precision Injury Signatures to Optimize Orthopaedic Interventions in Multiply Injured Patients (PRECISE STUDY)",
abstract = "Optimal timing and procedure selection that define staged treatment strategies can affect outcomes dramatically and remain an area of major debate in the treatment of multiply injured orthopaedic trauma patients. Decisions regarding timing and choice of orthopaedic procedure(s) are currently based on the physiologic condition of the patient, resource availability, and the expected magnitude of the intervention. Surgical decision-making algorithms rarely rely on precision-type data that account for demographics, magnitude of injury, and the physiologic/immunologic response to injury on a patient-specific basis. This study is a multicenter prospective investigation that will work toward developing a precision medicine approach to managing multiply injured patients by incorporating patient-specific indices that quantify (1) mechanical tissue damage volume; (2) cumulative hypoperfusion; (3) immunologic response; and (4) demographics. These indices will formulate a precision injury signature, unique to each patient, which will be explored for correspondence to outcomes and response to surgical interventions. The impact of the timing and magnitude of initial and staged surgical interventions on patient-specific physiologic and immunologic responses will be evaluated and described. The primary goal of the study will be the development of data-driven models that will inform clinical decision-making tools that can be used to predict outcomes and guide intervention decisions.",
keywords = "Damage control orthopaedics, Early appropriate care, Precision medicine",
author = "METRC and McKinley, {Todd O.} and Gaski, {Greg E.} and Billiar, {Timothy R.} and Yoram Vodovotz and Brown, {Krista M.} and Elster, {Eric A.} and Constantine, {Greg M.} and Schobel, {Seth A.} and Robertson, {Henry T.} and Meagher, {Ashley D.} and Reza Firoozabadi and Gary, {Joshua L.} and O-Toole, {Robert V.} and Arun Aneja and Trochez, {Karen M.} and Kempton, {Laurence B.} and Steenburg, {Scott D.} and Collins, {Susan C.} and Frey, {Katherine P.} and Castillo, {Renan C.} and Prism Schneider and Bosse, {Michael J.} and Cunningham, {Kyle W.} and Hsu, {Joseph R.} and Karunakar, {Madhav A.} and Phelps, {Kevin D.} and Runyon, {Michael S.} and Seymour, {Rachel B.} and Sims, {Stephen H.} and Christine Churchill and {Mirick Mueller}, {Gudrun E.} and Wagstrom, {Emily A.} and Kolettis, {George R.} and Natoli, {Roman M.} and Sorkin, {Anthony T.} and Virkus, {Walter W.} and Jennifer Beikes and Fentz, {Courteney L.} and Hill, {Lauren C.} and Warth, {Ryan J.} and Mayank Rao and Wade, {Charles E.} and Warner, {Stephen J.} and Boutte, {Sterling J.} and Hayden Stoeber and Joshua Rudnicki and Matuszewski, {Paul E.} and Teasdall, {Robert J.} and Lauren Allen and Carlini, {Anthony R.}",
note = "Funding Information: Carolinas Medical Center, Department of Orthopaedic Surgery, Atrium Health Musculoskeletal Institute: Melanie M. Hogg, MS for screening, collection of samples, and critical review of procedures and processes for implementation; Julia R. Raddatz, MS for enrollment and study setup; Indiana University Health Methodist Hospital: Jennifer L. Hartwell, MD for identification of eligible patients and assisting with enrollment; Rachel D. Rodriguez, MD for manuscript review; Jan P. Szatkowski, MD for enrollment and patient interaction; McGovern Medical School at The University of Texas Health Science Center at Houston: Keyla Guevara, RC for patient interaction and data collection; Garrett B. Jost, MD for patient enrollment; Guillermo R. Pechero Jr., MD for enrollment and patient interaction; April Vanderslice for IRB protocol management and research coordination; R Adams Cowley Shock Trauma Center at the University of Maryland: Nathan N. O-Hara, PhD, MHA for data acquisition; Leslie Sult, BSN, RN for her work as a Clinical Research Nurse Coordinator; University of Kentucky: Eric James Abbenhaus, MD for enrollment and data collection; Lucy C. Bowers, BS for enrollment; Gavin S. Hautala, MD for enrollment and data collection; Michael L. Raffetto, MD for screening, enrollment, local IRB protocol management, and data collection; Raymond D. Wright, Jr., MD for patient interaction; University of Washington Harborview Medical Center: Grant E. O-Keefe, MD for study oversight and manuscript review; Julie Agel, MA, ATC for regulatory compliance, patient follow-up, and assistance with enrollment protocols and problems; Vanderbilt University Medical Center: Robert H. Boyce, MD for enrollment and patient interaction; Elsa B. Rodriguez, MD for screening, enrollment, patient interaction, data collection, and sample management. Publisher Copyright: Copyright {\textcopyright} 2021 Wolters Kluwer Health, Inc. All rights reserved.",
year = "2022",
month = jan,
day = "1",
doi = "10.1097/BOT.0000000000002289",
language = "English (US)",
volume = "36",
pages = "S14--S20",
journal = "Journal of orthopaedic trauma",
issn = "0890-5339",
publisher = "Lippincott Williams and Wilkins",
}