Patient blood management program improves blood use and clinical outcomes in orthopedic surgery

Pranjal B. Gupta, Vince M. DeMario, Raj M. Amin, Eric A. Gehrie, Ruchika Goel, K. H. Ken Lee, William W. Yang, Harpal S. Khanuja, Robert S. Sterling, Paul M. Ness, Steven M. Frank

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Background: Although randomized trials show that patients do well when given less blood, there remains a persistent impression that orthopedic surgery patients require a higher hemoglobin transfusion threshold than other patient populations (8 g/dl vs. 7g/dl). Te authors tested the hypothesis in orthopedic patients that implementation of a patient blood management program encouraging a hemoglobin threshold less than 7 g/dl results in decreased blood use with no change in clinical outcomes. Methods: After launching a multifaceted patient blood management program, the authors retrospectively evaluated all adult orthopedic patients, comparing transfusion practices and clinical outcomes in the pre-and post-blood management cohorts. Risk adjustment accounted for age, sex, surgical procedure, and case mix index. Results: After patient blood management implementation, the mean hemoglobin threshold decreased from 7.8 ± 1.0 g/dl to 6.8 ± 1.0 g/dl (P < 0.0001). Erythrocyte use decreased by 32.5% (from 338 to 228 erythrocyte units per 1,000 patients; P = 0.0007). Clinical outcomes improved, with decreased morbidity (from 1.3% to 0.54%; P = 0.01), composite morbidity or mortality (from 1.5% to 0.75%; P = 0.035), and 30-day readmissions (from 9.0% to 5.8%; P = 0.0002). Improved outcomes were primarily recognized in patients 65 yr of age and older. After risk adjustment, patient blood management was independently associated with decreased composite morbidity or mortality (odds ratio, 0.44; 95% CI, 0.22 to 0.86; P = 0.016). Conclusions: In a retrospective study, patient blood management was associated with reduced blood use with similar or improved clinical outcomes in orthopedic surgery. A hemoglobin threshold of 7g/dl appears to be safe for many orthopedic patients.

Original languageEnglish (US)
Pages (from-to)1082-1091
Number of pages10
Issue number6
StatePublished - 2018

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine


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