TY - JOUR
T1 - Pathway to Totipotency
T2 - Lessons from Germ Cells
AU - Seydoux, Geraldine
AU - Braun, Robert E.
N1 - Funding Information:
We regret not citing many important primary references due to space limitations. We thank J. Priess, A. Nakamura, S. Mitinori, and S. Yoshida for communicating results before publication and M. Eddy for providing Figure 3A. We also thank the many participants of the Gordon, Keystone, and Cold Spring Harbor Germ Cells meetings, who have helped create a vibrant and interactive community. Research in the Seydoux and Braun labs is supported by the NIH. G.S. is an investigator of the Howard Hughes Medical Institute.
PY - 2006/12/1
Y1 - 2006/12/1
N2 - Oocytes and sperm are some of the most differentiated cells in our bodies, yet they generate all cell types after fertilization. Accumulating evidence suggests that this extraordinary potential is conferred to germ cells from the time of their formation during embryogenesis. In this Review, we describe common themes emerging from the study of germ cells in vertebrates and invertebrates. Transcriptional repression, chromatin remodeling, and an emphasis on posttranscriptional gene regulation preserve the totipotent genome of germ cells through generations.
AB - Oocytes and sperm are some of the most differentiated cells in our bodies, yet they generate all cell types after fertilization. Accumulating evidence suggests that this extraordinary potential is conferred to germ cells from the time of their formation during embryogenesis. In this Review, we describe common themes emerging from the study of germ cells in vertebrates and invertebrates. Transcriptional repression, chromatin remodeling, and an emphasis on posttranscriptional gene regulation preserve the totipotent genome of germ cells through generations.
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U2 - 10.1016/j.cell.2006.11.016
DO - 10.1016/j.cell.2006.11.016
M3 - Review article
C2 - 17129777
AN - SCOPUS:33751204468
SN - 0092-8674
VL - 127
SP - 891
EP - 904
JO - Cell
JF - Cell
IS - 5
ER -