Pathophysiology of keratoconus: What do we know today

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations


Keratoconus is a common corneal ectasia that leads to progressive visual impairment. Numerous studies have shown abnormal protein expression patterns in keratoconic corneas. However, the specific mechanisms causing this disease remain ambiguous. This review aims to provide an update on morphological studies of the keratoconic cornea, relate these early studies with current findings from proteomic, biochemical and cell culture studies and to postulate possible pathogenic pathways.

Original languageEnglish (US)
Pages (from-to)252-261
Number of pages10
JournalOpen Ophthalmology Journal
StatePublished - Jul 1 2017


  • Corneal epithelium
  • Cytokine
  • Keratoconus
  • Keratocytes
  • Morphology
  • Oxidative stress
  • Pathogenesis
  • Proteomics
  • TGF-β

ASJC Scopus subject areas

  • Ophthalmology


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