TY - JOUR
T1 - Pathophysiology of erectile dysfunction
AU - Matsui, Hotaka
AU - Sopko, Nikolai A.
AU - Hannan, Johanna L.
AU - Bivalacqua, Trinity J.
N1 - Funding Information:
*Supported by grants from the Fond de recherche en santt? du Quebec 01 Carrier), the Medical Research Council of Canada (DKBrock), and the National University ofSingapore (DI: Kour).
Publisher Copyright:
© 2015 Bentham Science Publishers
PY - 2015/5/1
Y1 - 2015/5/1
N2 - Erectile dysfunction (ED) is a major health problem as the population ages. Basic science research for the last two decades has expanded the knowledge on ED and identified several key molecular changes associated with the pathogenesis of ED, including nitric oxide (NO) / cyclic guanosine monophosphate (cGMP) / protein kinase G (PKG) pathway, RhoA/Rho-associated protein kinase (ROCK) signaling pathway, reactive oxygen species (ROS), renin-angiotensin system (RAS) and tumor necrosis factor-alpha (TNF-α). The causes of ED are classified into aging, vasculogenic, neuroenic, endocrinological, drug-induced and psychogenic. ED is often associated with systemic diseases, such as diabetes and cardiovascular diseases. In this review, we will review the molecular mechanisms of ED and known mechanisms behind ED associated with systemic diseases.
AB - Erectile dysfunction (ED) is a major health problem as the population ages. Basic science research for the last two decades has expanded the knowledge on ED and identified several key molecular changes associated with the pathogenesis of ED, including nitric oxide (NO) / cyclic guanosine monophosphate (cGMP) / protein kinase G (PKG) pathway, RhoA/Rho-associated protein kinase (ROCK) signaling pathway, reactive oxygen species (ROS), renin-angiotensin system (RAS) and tumor necrosis factor-alpha (TNF-α). The causes of ED are classified into aging, vasculogenic, neuroenic, endocrinological, drug-induced and psychogenic. ED is often associated with systemic diseases, such as diabetes and cardiovascular diseases. In this review, we will review the molecular mechanisms of ED and known mechanisms behind ED associated with systemic diseases.
KW - Angiotensin
KW - Erectile dysfunction
KW - Nitric oxide
KW - Pathophysiology
KW - Reactive oxygen species
KW - RhoA/Rho-associated protein kinase
KW - Tumor necrosis factor-alpha
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U2 - 10.2174/138945011605150504114041
DO - 10.2174/138945011605150504114041
M3 - Article
C2 - 25950641
AN - SCOPUS:84929666637
SN - 1389-4501
VL - 16
SP - 411
EP - 419
JO - Current Drug Targets
JF - Current Drug Targets
IS - 5
ER -