Pathophysiological roles of ectopic tachygastria induced with antral electrical stimulation

Hongbing Zhu, Hui Ouyang, J. D.Z. Chen

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Aim: To investigate the pathophysiological roles of tachygastria using antral electrical stimulation (AES). Methods: The study was performed on 13 healthy female hound-type dogs chronically implanted with three pairs of serosal electrodes and a gastric cannula (n = 7). In the first experiment (n = 7), the antral motility was measured for three 30-min periods right after a solid meal. AES was performed during the second 30-min period at a tachygastric frequency. In the second experiment (n = 6), gastric slow waves and animal behavior were monitored in the fasting state at baseline and with various parameters of AES. Results: (1) AES at tachygastric frequencies (7-14 cpm) significantly reduced the percentage of normal 4- to 6-cpm slow waves and induced tachygastria; (2) AES significantly and substantially inhibited the antral motility in the fed state; (3) AES in the fasting state energy dependently induced symptoms, and the symptom score was linearly correlated with the stimulation frequency, and (4) there was a significant negative correlation between percentage of tachygastria and index of antral motility. Conclusions: AES induces tachygastria and inhibits the antral motility. Tachygastria is correlated with antral motility.

Original languageEnglish (US)
Pages (from-to)192-198
Number of pages7
Issue number3
StatePublished - 2005
Externally publishedYes


  • Gastric electrical stimulation
  • Gastric motility
  • Gastric slow waves
  • Pathophysiological roles
  • Tachygastria

ASJC Scopus subject areas

  • Gastroenterology


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