@article{c8de198984734d239c6e328439534b3e,
title = "Pathogenic IL-23 signaling is required to initiate GM-CSF-driven autoimmune myocarditis in mice",
abstract = "Using a mouse model of experimental autoimmune myocarditis (EAM), we showed for the first time that IL-23 stimulation of CD4+ T cells is required only briefly at the initiation of GM-CFS-dependent cardiac autoimmunity. IL-23 signal, acting as a switch, turns on pathogenicity of CD4+ T cells, and becomes dispensable once autoreactivity is established. Il23a-/- mice failed to mount an efficient Th17 response to immunization, and were protected from myocarditis. However, remarkably, transient IL-23 stimulation ex vivo fully restored pathogenicity in otherwise nonpathogenic CD4+ T cells raised from Il23a-/- donors. Thus, IL-23 may no longer be necessary to uphold inflammation in established autoimmune diseases.",
keywords = "Autoimmunity, GM-CSF, IL-17A, IL-23, Myocarditis, Th17",
author = "Lei Wu and Diny, {Nicola L.} and Sufey Ong and Barin, {Jobert G.} and Xuezhou Hou and Rose, {Noel R.} and Talor, {Monica V.} and Daniela {\v C}ih{\'a}kov{\'a}",
note = "Funding Information: The authors would like to extend their gratitude to Pfizer Inc. for providing Il23a-/- mice; to Amgen Inc. for providing antimouse GM-CSF antibodies M250; to Dr. G. Christian Baldeviano for assistance with establishing transgenic mouse colonies; and to Xiaoling Zhang for assistance with flow cytometry. This work was supported by NIH/NHLBI Grants R01HL118183 (Daniela Cihakova), and R01HL113008 (Daniela Cihakova). N.L.D. is supported by predoctoral fellowship Grant 15PRE25400010 from the American Heart Association and the Richard J and Margaret Conn Himelfarb Student Support fund. X.H. is the current OLeary-Wilson Fellow in Autoimmune Disease Research in the Johns Hopkins Autoimmune Disease Research Center. L.W. was the OLeary-Wilson Fellow in Autoimmune Disease Research in the Johns Hopkins Autoimmune Disease Research Center from 2013 to 2014. S.O. was the recipient of Ruth L. Kirschstein National Research Service Award from NIH. Publisher Copyright: {\textcopyright} 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.",
year = "2016",
month = mar,
day = "1",
doi = "10.1002/eji.201545924",
language = "English (US)",
volume = "46",
pages = "582--592",
journal = "European Journal of Immunology",
issn = "0014-2980",
publisher = "Wiley-VCH Verlag",
number = "3",
}