Pathogenic consequences of Neisseria gonorrhoeae pilin glycan variation

Salil K. Ghosh, Jie Zhao, Mary C. Philogene, Abdulrahaman Alzaharani, Supriya Rane, Asesh Banerjee

Research output: Contribution to journalShort surveypeer-review

8 Scopus citations


A Neisseria gonorrhoeae (gonococcus, GC) pilin glycosylation gene, pgtA, can either possess or lack phase-variation ability. Many GC, particularly the disseminated strains, carry a phase-variable pgtA. However, other GC, predominantly the uncomplicated gonorrhea isolates, carry a pgtA lacking phase-variability. These and other results suggest GC pilin glycan's pathogenic involvement.

Original languageEnglish (US)
Pages (from-to)693-701
Number of pages9
JournalMicrobes and Infection
Issue number7
StatePublished - Jun 2004
Externally publishedYes


  • 2,4-diacetimido-2,4,6-trideoxyhexose
  • Av
  • DGI
  • GC
  • Gal
  • Glycosyl transferase
  • Glycosylation
  • Gonorrhea
  • Meningitis
  • Neisseria gonorrhoeae
  • Phase-variation
  • Pilin glycan
  • Pilus
  • Poly-G tract
  • antigenic-variation
  • disseminated gonococcal infection
  • galactose

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Infectious Diseases


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