Pathogenetic role for early focal macrophage infiltration in a pig model of arteriovenous fistula (AVF) stenosis

Prabir Roy-Chaudhury; Rao Khan; Begoña Campos; Yang Wang; Michelle Kurian; Timmy Lee; Lois Arend; Rino Munda

doi:10.5301/jva.5000151

Pathogenetic role for early focal macrophage infiltration in a pig model of arteriovenous fistula (AVF) stenosis

Prabir Roy-Chaudhury, Rao Khan, Begoña Campos, Yang Wang, Michelle Kurian, Timmy Lee, Lois Arend, Rino Munda

School of Medicine

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Purpose: Arteriovenous fistula non-maturation because of a peri-anastomotic venous stenosis is currently a huge clinical problem for which there are no effective therapies. Methods: In an attempt to further define the cellular pathways involved in this process we have assessed the pattern and intensity of macrophage infiltration at different time points in a pig model of AVF stenosis. Results: Our results demonstrate an early and eccentric pattern of macrophage infiltration at 2d with a rapid disappearance of this infiltrate by 7d. Conclusion: We suggest that this early and eccentric macrophage infiltration could play an important role in the pathogenesis of AVF non-maturation.

Original language	English (US)
Pages (from-to)	25-28
Number of pages	4
Journal	Journal of Vascular Access
Volume	15
Issue number	1
DOIs	https://doi.org/10.5301/jva.5000151
State	Published - 2014

Keywords

Arteriovenous fistula
Infiltration
Macrophage
Pig
Stenosis

ASJC Scopus subject areas

Surgery
Nephrology

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10.5301/jva.5000151

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title = "Pathogenetic role for early focal macrophage infiltration in a pig model of arteriovenous fistula (AVF) stenosis",

abstract = "Purpose: Arteriovenous fistula non-maturation because of a peri-anastomotic venous stenosis is currently a huge clinical problem for which there are no effective therapies. Methods: In an attempt to further define the cellular pathways involved in this process we have assessed the pattern and intensity of macrophage infiltration at different time points in a pig model of AVF stenosis. Results: Our results demonstrate an early and eccentric pattern of macrophage infiltration at 2d with a rapid disappearance of this infiltrate by 7d. Conclusion: We suggest that this early and eccentric macrophage infiltration could play an important role in the pathogenesis of AVF non-maturation.",

keywords = "Arteriovenous fistula, Infiltration, Macrophage, Pig, Stenosis",

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T1 - Pathogenetic role for early focal macrophage infiltration in a pig model of arteriovenous fistula (AVF) stenosis

AU - Roy-Chaudhury, Prabir

AU - Khan, Rao

AU - Campos, Begoña

AU - Wang, Yang

AU - Kurian, Michelle

AU - Lee, Timmy

AU - Arend, Lois

AU - Munda, Rino

PY - 2014

Y1 - 2014

N2 - Purpose: Arteriovenous fistula non-maturation because of a peri-anastomotic venous stenosis is currently a huge clinical problem for which there are no effective therapies. Methods: In an attempt to further define the cellular pathways involved in this process we have assessed the pattern and intensity of macrophage infiltration at different time points in a pig model of AVF stenosis. Results: Our results demonstrate an early and eccentric pattern of macrophage infiltration at 2d with a rapid disappearance of this infiltrate by 7d. Conclusion: We suggest that this early and eccentric macrophage infiltration could play an important role in the pathogenesis of AVF non-maturation.

AB - Purpose: Arteriovenous fistula non-maturation because of a peri-anastomotic venous stenosis is currently a huge clinical problem for which there are no effective therapies. Methods: In an attempt to further define the cellular pathways involved in this process we have assessed the pattern and intensity of macrophage infiltration at different time points in a pig model of AVF stenosis. Results: Our results demonstrate an early and eccentric pattern of macrophage infiltration at 2d with a rapid disappearance of this infiltrate by 7d. Conclusion: We suggest that this early and eccentric macrophage infiltration could play an important role in the pathogenesis of AVF non-maturation.

KW - Arteriovenous fistula

KW - Infiltration

KW - Macrophage

KW - Pig

KW - Stenosis

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Pathogenetic role for early focal macrophage infiltration in a pig model of arteriovenous fistula (AVF) stenosis

Abstract

Keywords

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