Pathogenesis of SIVmac Infection in Chinese and Indian Rhesus Macaques: Effects of Splenectomy on Virus Burden

S. V. Joag; E. B. Stephens; R. J. Adams; L. Foresman; O. Narayan

doi:10.1006/viro.1994.1207

Pathogenesis of SIV_mac Infection in Chinese and Indian Rhesus Macaques: Effects of Splenectomy on Virus Burden

S. V. Joag, E. B. Stephens, R. J. Adams, L. Foresman, O. Narayan

School of Medicine

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125 Scopus citations

Abstract

The spleen and lymph nodes are the predominant sites of viral replication in SIV and HIV infections. We studied splenectomized and control unsplenectomized rhesus macaques of both the Indian and the Chinese subspecies of Macaca mulatta. All animals were inoculated with SIV_mac239, a molecularly cloned strain of SIV. Our data showed: (1) splenectomized animals, particularly among the Indian subspecies, had a lower virus burden and longer survival than unsplenectomized controls, (2) the Chinese macaques controlled virus replication more effectively than did the Indian animals, and (3) that a higher infectious virus burden was present in LN/spleen than in blood in both splenectomized and control animals.

Original language	English (US)
Article number	71207
Pages (from-to)	436-446
Number of pages	11
Journal	Virology
Volume	200
Issue number	2
DOIs	https://doi.org/10.1006/viro.1994.1207
State	Published - May 1 1994

ASJC Scopus subject areas

Virology

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title = "Pathogenesis of SIVmac Infection in Chinese and Indian Rhesus Macaques: Effects of Splenectomy on Virus Burden",

abstract = "The spleen and lymph nodes are the predominant sites of viral replication in SIV and HIV infections. We studied splenectomized and control unsplenectomized rhesus macaques of both the Indian and the Chinese subspecies of Macaca mulatta. All animals were inoculated with SIVmac239, a molecularly cloned strain of SIV. Our data showed: (1) splenectomized animals, particularly among the Indian subspecies, had a lower virus burden and longer survival than unsplenectomized controls, (2) the Chinese macaques controlled virus replication more effectively than did the Indian animals, and (3) that a higher infectious virus burden was present in LN/spleen than in blood in both splenectomized and control animals.",

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T1 - Pathogenesis of SIVmac Infection in Chinese and Indian Rhesus Macaques

T2 - Effects of Splenectomy on Virus Burden

AU - Joag, S. V.

AU - Stephens, E. B.

AU - Adams, R. J.

AU - Foresman, L.

AU - Narayan, O.

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AB - The spleen and lymph nodes are the predominant sites of viral replication in SIV and HIV infections. We studied splenectomized and control unsplenectomized rhesus macaques of both the Indian and the Chinese subspecies of Macaca mulatta. All animals were inoculated with SIVmac239, a molecularly cloned strain of SIV. Our data showed: (1) splenectomized animals, particularly among the Indian subspecies, had a lower virus burden and longer survival than unsplenectomized controls, (2) the Chinese macaques controlled virus replication more effectively than did the Indian animals, and (3) that a higher infectious virus burden was present in LN/spleen than in blood in both splenectomized and control animals.

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Pathogenesis of SIV_mac Infection in Chinese and Indian Rhesus Macaques: Effects of Splenectomy on Virus Burden

Abstract

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