Pathobiology of CNS Human Immunodeficiency Virus Infection

Jennifer L. Lyons; Luis B. Tovar-y-Romo; Kiran T. Thakur; Justin C. McArthur; Norman J. Haughey

doi:10.1016/B978-0-12-398270-4.00028-8

Pathobiology of CNS Human Immunodeficiency Virus Infection

Jennifer L. Lyons, Luis B. Tovar-y-Romo, Kiran T. Thakur, Justin C. McArthur, Norman J. Haughey

Research output: Chapter in Book/Report/Conference proceeding › Chapter

3 Scopus citations

Abstract

HIV-mediated CNS damage is a result of a combination of direct invasion of the brain by the virus and chronic immune activation leading to in situ cerebral inflammatory reactions. This can manifest clinically as chronic cognitive and/or motor impairment, and given the delicate balance of the CNS milieu, it can result in compartmentalized infection or reservoir establishment, or both. The interactions among the virus, the host immune system, and the cells of the CNS, together with effects on host metabolism, are detailed in this chapter. The implications this has on clinically overt neurological dysfunction and the effects of antiretroviral therapy are also described.

Original language	English (US)
Title of host publication	Neurobiology of Brain Disorders
Subtitle of host publication	Biological Basis of Neurological and Psychiatric Disorders
Publisher	Elsevier Inc.
Pages	444-466
Number of pages	23
ISBN (Electronic)	9780123982803
ISBN (Print)	9780123982704
DOIs	https://doi.org/10.1016/B978-0-12-398270-4.00028-8
State	Published - 2015
Externally published	Yes

Keywords

Astrogliosis
CNS lipid metabolism
Chronic immune activation
Combination antiretroviral therapy
HIV infection
HIV-associated neurological disorder

ASJC Scopus subject areas

General Medicine

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10.1016/B978-0-12-398270-4.00028-8

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title = "Pathobiology of CNS Human Immunodeficiency Virus Infection",

abstract = "HIV-mediated CNS damage is a result of a combination of direct invasion of the brain by the virus and chronic immune activation leading to in situ cerebral inflammatory reactions. This can manifest clinically as chronic cognitive and/or motor impairment, and given the delicate balance of the CNS milieu, it can result in compartmentalized infection or reservoir establishment, or both. The interactions among the virus, the host immune system, and the cells of the CNS, together with effects on host metabolism, are detailed in this chapter. The implications this has on clinically overt neurological dysfunction and the effects of antiretroviral therapy are also described.",

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AU - Lyons, Jennifer L.

AU - Tovar-y-Romo, Luis B.

AU - Thakur, Kiran T.

AU - McArthur, Justin C.

AU - Haughey, Norman J.

PY - 2015

Y1 - 2015

N2 - HIV-mediated CNS damage is a result of a combination of direct invasion of the brain by the virus and chronic immune activation leading to in situ cerebral inflammatory reactions. This can manifest clinically as chronic cognitive and/or motor impairment, and given the delicate balance of the CNS milieu, it can result in compartmentalized infection or reservoir establishment, or both. The interactions among the virus, the host immune system, and the cells of the CNS, together with effects on host metabolism, are detailed in this chapter. The implications this has on clinically overt neurological dysfunction and the effects of antiretroviral therapy are also described.

AB - HIV-mediated CNS damage is a result of a combination of direct invasion of the brain by the virus and chronic immune activation leading to in situ cerebral inflammatory reactions. This can manifest clinically as chronic cognitive and/or motor impairment, and given the delicate balance of the CNS milieu, it can result in compartmentalized infection or reservoir establishment, or both. The interactions among the virus, the host immune system, and the cells of the CNS, together with effects on host metabolism, are detailed in this chapter. The implications this has on clinically overt neurological dysfunction and the effects of antiretroviral therapy are also described.

KW - Astrogliosis

KW - CNS lipid metabolism

KW - Chronic immune activation

KW - Combination antiretroviral therapy

KW - HIV infection

KW - HIV-associated neurological disorder

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ER -

Pathobiology of CNS Human Immunodeficiency Virus Infection

Abstract

Keywords

ASJC Scopus subject areas

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