TY - JOUR
T1 - Particulate matter and risk of Parkinson disease in a large prospective study of women
AU - Palacios, Natalia
AU - Fitzgerald, Kathryn C.
AU - Hart, Jaime E.
AU - Weisskopf, Marc G.
AU - Schwarzschild, Michael A.
AU - Ascherio, Alberto
AU - Laden, Francine
N1 - Funding Information:
Dr. Palacios reports no disclosures. Dr. Hart reports no disclosures. Ms. Fitzgerald reports no disclosures. Dr. Weisskopf reports no disclosures. Dr. Schwarzschild has received funding from the Michael J. Fox Foundation, Parkinson Disease Foundation, the RJG Parkinson’s Disease Foundation, and the Parkinson Disease Foundation program, Parkinson’s Disease Foundation Parkinson’s research program. Dr. Ascherio has received honoraria for speaking at scientific symposia by Roche, Sanofi Aventis, Serono, and Almirall and has received research funding from the ALS Therapy Alliance, the Michael J. Fox Foundation, and the National Institutes of Health. Dr. Laden reports no disclosures.
Funding Information:
The authors would like to acknowledge Leslie Unger for administrative support and Dr. Eilis O’Reilly for statistical advice. Study Funding: Supported by NIH (K01ES019183).
Publisher Copyright:
© 2014 Palacios et al.
PY - 2014
Y1 - 2014
N2 - Background: Exposure to air pollution has been implicated in a number of adverse health outcomes and the effect of particulate matter (PM) on the brain is beginning to be recognized. Yet, no prospective study has examined the association between PM and risk of Parkinson Disease. Thus, our goal was assess if exposure to particulate matter air pollution is related to risk of Parkinson's disease (PD) in the Nurses' Health Study (NHS), a large prospective cohort of women. Methods: Cumulative average exposure to different size fractions of PM up to 2 years before the onset of PD, was estimated using a spatio-Temporal model by linking each individual's places of residence throughout the study with location-specific air pollution levels. We prospectively followed 115,767 women in the NHS, identified 508 incident PD cases and used multivariable Cox proportional hazards models to estimate the risk of PD associated with each size fraction of PM independently. Results: In models adjusted for age in months, smoking, region, population density, caffeine and ibuprofen intake, we observed no statistically significant associations between exposure to air pollution and PD risk. The relative risk (RR) comparing the top quartile to the bottom quartile of PM exposure was 1.03 (95% Confidence Intervals (CI): 0.78, 1.37) for PM10 (le; 10 microns in diameter), 1.10 (95% CI: 0.83, 1.45) for PM2.5 (le; 2.5 microns in diameter), and 0.93 (95% CI: 0.69, 1.26) for PM10-2.5 (2.5 to 10 microns in diameter). Conclusions: In this study, we found no evidence that exposure to air pollution is a risk factor for PD.
AB - Background: Exposure to air pollution has been implicated in a number of adverse health outcomes and the effect of particulate matter (PM) on the brain is beginning to be recognized. Yet, no prospective study has examined the association between PM and risk of Parkinson Disease. Thus, our goal was assess if exposure to particulate matter air pollution is related to risk of Parkinson's disease (PD) in the Nurses' Health Study (NHS), a large prospective cohort of women. Methods: Cumulative average exposure to different size fractions of PM up to 2 years before the onset of PD, was estimated using a spatio-Temporal model by linking each individual's places of residence throughout the study with location-specific air pollution levels. We prospectively followed 115,767 women in the NHS, identified 508 incident PD cases and used multivariable Cox proportional hazards models to estimate the risk of PD associated with each size fraction of PM independently. Results: In models adjusted for age in months, smoking, region, population density, caffeine and ibuprofen intake, we observed no statistically significant associations between exposure to air pollution and PD risk. The relative risk (RR) comparing the top quartile to the bottom quartile of PM exposure was 1.03 (95% Confidence Intervals (CI): 0.78, 1.37) for PM10 (le; 10 microns in diameter), 1.10 (95% CI: 0.83, 1.45) for PM2.5 (le; 2.5 microns in diameter), and 0.93 (95% CI: 0.69, 1.26) for PM10-2.5 (2.5 to 10 microns in diameter). Conclusions: In this study, we found no evidence that exposure to air pollution is a risk factor for PD.
KW - Cohort studies
KW - Epidemiology
KW - Incidence studies
KW - Parkinson disease/Parkinsonism
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U2 - 10.1186/1476-069X-13-80
DO - 10.1186/1476-069X-13-80
M3 - Article
C2 - 25294559
AN - SCOPUS:84925227837
SN - 1476-069X
VL - 13
JO - Environmental Health: A Global Access Science Source
JF - Environmental Health: A Global Access Science Source
IS - 1
M1 - 80
ER -