Particulate bioglass stimulate IL-1α and the TNFα secretion in human synoviocytes

S. P. Bendall; M. G. Gaies; C. Frondoza; R. H. Jinnah; D. S. Hungerford

Particulate bioglass stimulate IL-1α and the TNFα secretion in human synoviocytes

S. P. Bendall, M. G. Gaies, C. Frondoza, R. H. Jinnah, D. S. Hungerford

School of Medicine

Research output: Contribution to conference › Paper › peer-review

Abstract

One of the disadvantages of using bioglass as an implant coating material is that it is a highly resorbable ceramic that can fragment into particulate debris in vivo and stimulate inflammatory and osteolytic response. An experiment was conducted to determine whether particulate bioactive glass elicits an inflammatory response using human synoviocytes as target tissue cells. Synoviocytes were isolated from synovial tissue of a rheumatoid arthritic patient undergoing joint replacement surgery. Particulate bioglass was found to have minimal inhibitory effect on the proliferation of human synoviocytes. However, bioglass was found to induce an inflammatory response as shown by the release of cytokines TNFα and Il-1α.

Original language	English (US)
Number of pages	1
State	Published - Dec 1 1996
Event	Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2) - Toronto, Can Duration: May 29 1996 → Jun 2 1996

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Other	Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2)
City	Toronto, Can
Period	5/29/96 → 6/2/96

ASJC Scopus subject areas

General Materials Science

Cite this

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title = "Particulate bioglass stimulate IL-1α and the TNFα secretion in human synoviocytes",

abstract = "One of the disadvantages of using bioglass as an implant coating material is that it is a highly resorbable ceramic that can fragment into particulate debris in vivo and stimulate inflammatory and osteolytic response. An experiment was conducted to determine whether particulate bioactive glass elicits an inflammatory response using human synoviocytes as target tissue cells. Synoviocytes were isolated from synovial tissue of a rheumatoid arthritic patient undergoing joint replacement surgery. Particulate bioglass was found to have minimal inhibitory effect on the proliferation of human synoviocytes. However, bioglass was found to induce an inflammatory response as shown by the release of cytokines TNFα and Il-1α.",

author = "Bendall, {S. P.} and Gaies, {M. G.} and C. Frondoza and Jinnah, {R. H.} and Hungerford, {D. S.}",

year = "1996",

month = dec,

day = "1",

language = "English (US)",

note = "Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2) ; Conference date: 29-05-1996 Through 02-06-1996",

}

TY - CONF

T1 - Particulate bioglass stimulate IL-1α and the TNFα secretion in human synoviocytes

AU - Bendall, S. P.

AU - Gaies, M. G.

AU - Frondoza, C.

AU - Jinnah, R. H.

AU - Hungerford, D. S.

PY - 1996/12/1

Y1 - 1996/12/1

N2 - One of the disadvantages of using bioglass as an implant coating material is that it is a highly resorbable ceramic that can fragment into particulate debris in vivo and stimulate inflammatory and osteolytic response. An experiment was conducted to determine whether particulate bioactive glass elicits an inflammatory response using human synoviocytes as target tissue cells. Synoviocytes were isolated from synovial tissue of a rheumatoid arthritic patient undergoing joint replacement surgery. Particulate bioglass was found to have minimal inhibitory effect on the proliferation of human synoviocytes. However, bioglass was found to induce an inflammatory response as shown by the release of cytokines TNFα and Il-1α.

AB - One of the disadvantages of using bioglass as an implant coating material is that it is a highly resorbable ceramic that can fragment into particulate debris in vivo and stimulate inflammatory and osteolytic response. An experiment was conducted to determine whether particulate bioactive glass elicits an inflammatory response using human synoviocytes as target tissue cells. Synoviocytes were isolated from synovial tissue of a rheumatoid arthritic patient undergoing joint replacement surgery. Particulate bioglass was found to have minimal inhibitory effect on the proliferation of human synoviocytes. However, bioglass was found to induce an inflammatory response as shown by the release of cytokines TNFα and Il-1α.

UR - http://www.scopus.com/inward/record.url?scp=0030385294&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030385294&partnerID=8YFLogxK

M3 - Paper

AN - SCOPUS:0030385294

T2 - Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2)

Y2 - 29 May 1996 through 2 June 1996

ER -

Particulate bioglass stimulate IL-1α and the TNFα secretion in human synoviocytes

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ASJC Scopus subject areas

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