Part one: Genomics of oxygen sensing

Gregg L Semenza

Part one: Genomics of oxygen sensing

School of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Intracellular O₂ concentrations in humans and other mammals are maintained within a relatively narrow range, with partial pressures of O₂ varying between a high of approximately 110mmHg, (16% O₂ at sea level) in the pulmonary alveoli to a low of less than 20mmHg. (3% O₂) in some areas of the heart, kidney, and brain. The physiological O₂ concentration within any cell reflects the net effect of O₂ delivery and O₂ consumption and is associated with adaptive intracellular responses to protect against the deleterious effects of O₂ deprivation (hypoxia) or O₂ excess (hyperoxia). Oxygen homeostasis thus reflects the requirement for O₂ as a substrate for essential biochemical reactions, most notably oxidative phosphorylation, which is balanced by the risk of oxidative damage to cellular macromolecules. The molecular mechanisms underlying homeostatic responses to hypoxia represent the central focus of this volume.

Original language	English (US)
Title of host publication	Oxygen Sensing
Subtitle of host publication	Responses and Adaption to Hypoxia
Publisher	CRC Press
Pages	1-5
Number of pages	5
ISBN (Electronic)	9780824748456
ISBN (Print)	9780824709600
State	Published - Jan 1 2003

ASJC Scopus subject areas

General Medicine

Cite this

@inbook{ab1d92f4240e4857a5f9078657624edf,

title = "Part one: Genomics of oxygen sensing",

abstract = "Intracellular O2 concentrations in humans and other mammals are maintained within a relatively narrow range, with partial pressures of O2 varying between a high of approximately 110mmHg, (16% O2 at sea level) in the pulmonary alveoli to a low of less than 20mmHg. (3% O2) in some areas of the heart, kidney, and brain. The physiological O2 concentration within any cell reflects the net effect of O2 delivery and O2 consumption and is associated with adaptive intracellular responses to protect against the deleterious effects of O2 deprivation (hypoxia) or O2 excess (hyperoxia). Oxygen homeostasis thus reflects the requirement for O2 as a substrate for essential biochemical reactions, most notably oxidative phosphorylation, which is balanced by the risk of oxidative damage to cellular macromolecules. The molecular mechanisms underlying homeostatic responses to hypoxia represent the central focus of this volume.",

author = "Semenza, {Gregg L}",

year = "2003",

month = jan,

day = "1",

language = "English (US)",

isbn = "9780824709600",

pages = "1--5",

booktitle = "Oxygen Sensing",

publisher = "CRC Press",

address = "United States",

}

TY - CHAP

T1 - Part one

T2 - Genomics of oxygen sensing

AU - Semenza, Gregg L

PY - 2003/1/1

Y1 - 2003/1/1

N2 - Intracellular O2 concentrations in humans and other mammals are maintained within a relatively narrow range, with partial pressures of O2 varying between a high of approximately 110mmHg, (16% O2 at sea level) in the pulmonary alveoli to a low of less than 20mmHg. (3% O2) in some areas of the heart, kidney, and brain. The physiological O2 concentration within any cell reflects the net effect of O2 delivery and O2 consumption and is associated with adaptive intracellular responses to protect against the deleterious effects of O2 deprivation (hypoxia) or O2 excess (hyperoxia). Oxygen homeostasis thus reflects the requirement for O2 as a substrate for essential biochemical reactions, most notably oxidative phosphorylation, which is balanced by the risk of oxidative damage to cellular macromolecules. The molecular mechanisms underlying homeostatic responses to hypoxia represent the central focus of this volume.

AB - Intracellular O2 concentrations in humans and other mammals are maintained within a relatively narrow range, with partial pressures of O2 varying between a high of approximately 110mmHg, (16% O2 at sea level) in the pulmonary alveoli to a low of less than 20mmHg. (3% O2) in some areas of the heart, kidney, and brain. The physiological O2 concentration within any cell reflects the net effect of O2 delivery and O2 consumption and is associated with adaptive intracellular responses to protect against the deleterious effects of O2 deprivation (hypoxia) or O2 excess (hyperoxia). Oxygen homeostasis thus reflects the requirement for O2 as a substrate for essential biochemical reactions, most notably oxidative phosphorylation, which is balanced by the risk of oxidative damage to cellular macromolecules. The molecular mechanisms underlying homeostatic responses to hypoxia represent the central focus of this volume.

UR - http://www.scopus.com/inward/record.url?scp=85057682206&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85057682206&partnerID=8YFLogxK

M3 - Chapter

AN - SCOPUS:85057682206

SN - 9780824709600

SP - 1

EP - 5

BT - Oxygen Sensing

PB - CRC Press

ER -

Part one: Genomics of oxygen sensing

Abstract

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this