Parkinson's disease: depletion of substantia nigra neurotensin receptors

G. R. Uhl; P. J. Whitehouse; D. L. Price; W. W. Tourtelotte; M. J. Kuhar

doi:10.1016/0006-8993(84)90935-1

Parkinson's disease: depletion of substantia nigra neurotensin receptors

G. R. Uhl
, P. J. Whitehouse
, D. L. Price
, W. W. Tourtelotte
, M. J. Kuhar

School of Medicine

Research output: Contribution to journal › Article › peer-review

74 Scopus citations

Abstract

Neurotensin receptor autoradiography reveals dense binding in normal human substantia nigra. In nigra from patients with Parkinson's disease, nigral receptor binding is only about one-third of control values. 'Saturation' analysis suggests that these changes result from receptor loss. These results support a neurotensin-domapine interaction in human nigro-striatal circuits.

Original language	English (US)
Pages (from-to)	186-190
Number of pages	5
Journal	Brain Research
Volume	308
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(84)90935-1
State	Published - Aug 6 1984

Keywords

Parkinson's disease
neurotensin
peptide
receptor autoradiography
substantia nigra

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(84)90935-1

Cite this

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title = "Parkinson's disease: depletion of substantia nigra neurotensin receptors",

abstract = "Neurotensin receptor autoradiography reveals dense binding in normal human substantia nigra. In nigra from patients with Parkinson's disease, nigral receptor binding is only about one-third of control values. 'Saturation' analysis suggests that these changes result from receptor loss. These results support a neurotensin-domapine interaction in human nigro-striatal circuits.",

keywords = "Parkinson's disease, neurotensin, peptide, receptor autoradiography, substantia nigra",

author = "Uhl, \{G. R.\} and Whitehouse, \{P. J.\} and Price, \{D. L.\} and Tourtelotte, \{W. W.\} and Kuhar, \{M. J.\}",

note = "Funding Information: We thankG all Hackneya nd Naomi Taylor for ex-cellentt echnicaal ssistancea,n d Darlcnc Weimerf or carefulm anuscrippt reparationT.h is \textasciitilde{}ork was supported by grants from the McKnight Foundation, AmericanP arkinsonD iseaseA ssociationa nd NIH GrantsM H25951a nd MH00053.",

year = "1984",

month = aug,

day = "6",

doi = "10.1016/0006-8993(84)90935-1",

language = "English (US)",

volume = "308",

pages = "186--190",

journal = "Brain Research",

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T2 - depletion of substantia nigra neurotensin receptors

AU - Uhl, G. R.

AU - Whitehouse, P. J.

AU - Price, D. L.

AU - Tourtelotte, W. W.

AU - Kuhar, M. J.

N1 - Funding Information: We thankG all Hackneya nd Naomi Taylor for ex-cellentt echnicaal ssistancea,n d Darlcnc Weimerf or carefulm anuscrippt reparationT.h is ~ork was supported by grants from the McKnight Foundation, AmericanP arkinsonD iseaseA ssociationa nd NIH GrantsM H25951a nd MH00053.

PY - 1984/8/6

Y1 - 1984/8/6

N2 - Neurotensin receptor autoradiography reveals dense binding in normal human substantia nigra. In nigra from patients with Parkinson's disease, nigral receptor binding is only about one-third of control values. 'Saturation' analysis suggests that these changes result from receptor loss. These results support a neurotensin-domapine interaction in human nigro-striatal circuits.

AB - Neurotensin receptor autoradiography reveals dense binding in normal human substantia nigra. In nigra from patients with Parkinson's disease, nigral receptor binding is only about one-third of control values. 'Saturation' analysis suggests that these changes result from receptor loss. These results support a neurotensin-domapine interaction in human nigro-striatal circuits.

KW - Parkinson's disease

KW - neurotensin

KW - peptide

KW - receptor autoradiography

KW - substantia nigra

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ER -

Parkinson's disease: depletion of substantia nigra neurotensin receptors

Abstract

Keywords

ASJC Scopus subject areas

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